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1. (WO2016054083) METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2016/054083 International Application No.: PCT/US2015/053007
Publication Date: 07.04.2016 International Filing Date: 29.09.2015
IPC:
A61K 31/155 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
155
Amidines (), e.g. guanidine (H2N-C(NH)-NH2), isourea (HNC(OH)NH2), isothiourea (HNC(SH)-NH2)
Applicants:
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US/US]; 412 Low Memorial Library 535 West 116th Street New York, New York 10027, US
Inventors:
HENDERSON, Christopher; US
WICHTERLE, Hynek; US
OAKLEY, Derek; US
Agent:
HOOPER, Kevin; US
Priority Data:
62/057,50930.09.2014US
Title (EN) METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS
(FR) MÉTHODES ET COMPOSITIONS PHARMACEUTIQUES POUR TRAITER LA SCLÉROSE LATÉRALE AMYOTROPHIQUE
Abstract:
(EN) The present disclosure provides, inter alia, methods and pharmaceutical compositions for treating or ameliorating amyotrophic lateral sclerosis (ALS). Among the various aspects of the present disclosure is the provision of methods and pharmaceutical compositions for treating or ameliorating ALS. Briefly, therefore, the present disclosure is directed to a method for treating or ameliorating an effect of amyotrophic lateral sclerosis (ALS) comprising administering to a subject in need thereof a modulator of a gene selected from the group consisting of Phospholipase D1 (PLD1).
(FR) La présente invention concerne notamment des méthodes et des compositions pharmaceutiques pour le traitement ou l'amélioration de la sclérose latérale amyotrophique (ALS). L'invention porte en particulier, parmi ses divers aspects, sur la fourniture de méthodes et de compositions pharmaceutiques pour le traitement ou l'amélioration de l'ALS. En résumé, la présente invention a trait à une méthode destinée à traiter ou améliorer un effet de la sclérose latérale amyotrophique (ALS), comprenant l'administration, à un sujet nécessitant un tel traitement, d'un modulateur d'un gène choisi dans le groupe constitué par la Phospholipase D1 (PLD1).
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)