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1. (WO2016054055) PREDICTION OF RESPONSE TO PARP INHIBITORS AND COMBINATIONAL THERAPY TARGETING C-MET AND PARP1
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2016/054055 International Application No.: PCT/US2015/052966
Publication Date: 07.04.2016 International Filing Date: 29.09.2015
IPC:
A61P 35/00 (2006.01)
Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM[US/US]; 201 West 7th St. Austin, TX 78701, US
Inventors: HUNG, Mien-Chie; US
DU, Yi; US
Agent: JOYNER, Amanda; US
Priority Data:
62/057,03729.09.2014US
Title (EN) PREDICTION OF RESPONSE TO PARP INHIBITORS AND COMBINATIONAL THERAPY TARGETING C-MET AND PARP1
(FR) PRÉDICTION DE LA RÉPONSE AUX INHIBITEURS DE PARP ET TRAITEMENT COMBINÉ CIBLANT C-MET ET PARP1
Abstract: front page image
(EN) Provided herein are methods for identifying and treating cancers that are resistant to PARP inhibition. Methods for sensitizing cancers to a PARP inhibitor therapy are also provided. In some aspects, PARP inhibitor cancers are treated with a PARP inhibitor therapy in combination with a c-Met inhibitor therapy.
(FR) La présente invention concerne des méthodes permettant d'identifier et de traiter les cancers qui sont résistants à l'inhibition de PARP. L'invention concerne également des méthodes permettant de sensibiliser les cancers à un traitement sous inhibiteur de PARP. Dans certains aspects, les cancers qui sont résistants à l'inhibition de PARP sont traités avec un traitement sous inhibiteur de PARP en association avec un traitement sous inhibiteur de c-Met.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)