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1. (WO2016053855) SPHINGOSINE-1-PHOSPATE RECEPTOR MODULATORS FOR TREATMENT OF CARDIOPULMONARY DISORDERS

Pub. No.:    WO/2016/053855    International Application No.:    PCT/US2015/052611
Publication Date: Fri Apr 08 01:59:59 CEST 2016 International Filing Date: Tue Sep 29 01:59:59 CEST 2015
IPC: C09B 11/00
Applicants: THE SCRIPPS RESEARCH INSTITUTE
Inventors: ROBERTS, Edward
ROSEN, Hugh
URBANO, Mariangela
GUERRERO, Miguel, A.
Title: SPHINGOSINE-1-PHOSPATE RECEPTOR MODULATORS FOR TREATMENT OF CARDIOPULMONARY DISORDERS
Abstract:
The invention provides compounds effective as sphingosine-1 -phosphate receptor modulators for treatment of cardiopulmonary diseases, such as hypertension (including malignant hypertension), angina, myocardial infarction, cardiac arrhythmias, congestive heart failure, coronary heart disease, atherosclerosis, angina pectoris, dysrhythmias, cardiomyothopy (including hypertropic cardiomyothopy), heart failure, cardiac arrest, bronchitis, asthma, chronic obstructive pulmonary disease, cystic fibrosis, croup, emphysema, pleurisy, pulmonary fibrosis, pneumonia, pulmonary embolus, pulmonary hypertension, mesothelioma, ventricular conduction abnormalities, complete heart block, adult respiratory distress syndrome, sepsis syndrome, idiopathic pulmonary fibrosis, scleroderma, systemic sclerosis, retroperitoneal fibrosis, prevention of keloid formation, or cirrhosis.