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1. (WO2016052930) METHOD FOR PREPARING HIGH-PURITY (R)-9-[2-(PHOSPHONOMETHOXY)PROPYL]ADENINE

Pub. No.:    WO/2016/052930    International Application No.:    PCT/KR2015/010114
Publication Date: Fri Apr 08 01:59:59 CEST 2016 International Filing Date: Fri Sep 25 01:59:59 CEST 2015
IPC: C07F 9/6561
C07F 9/38
C07D 473/34
A61K 31/52
Applicants: HANMI FINE CHEMICAL CO., LTD.
한미정밀화학주식회사
Inventors: CHOI, Won Kyoung
최원경
PARK, Eunrang
박은랑
CHO, Young Bum
조영범
LEE, Jaeheon
이재헌
CHANG, Young-kil
장영길
Title: METHOD FOR PREPARING HIGH-PURITY (R)-9-[2-(PHOSPHONOMETHOXY)PROPYL]ADENINE
Abstract:
The present invention relates to a method for preparing high-purity (R)-9-[2-(phosphonomethoxy)propyl]adenine (PMPA). Since (diethoxyphosphoryl)methyl naphthalene-1-sulfonate or (diethoxyphosphoryl)methyl naphthalene-2-sulfonate, which has high purity due to an easy reaction process and fewer impurities generated in the reaction, is used as an intermediate, high-purity PMPA can be prepared. In addition, since the PMPA prepared by the method of the present invention has very high purity, tenofovir diisopropyl and acid adduct salts thereof can be prepared at high purity by using the PMPA, and thus the PMPA is very advantageous in producing high-quality raw material medicines.