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|1. (WO2016052930) METHOD FOR PREPARING HIGH-PURITY (R)-9-[2-(PHOSPHONOMETHOXY)PROPYL]ADENINE|
|Applicants:||HANMI FINE CHEMICAL CO., LTD.
|Inventors:||CHOI, Won Kyoung
CHO, Young Bum
|Title:||METHOD FOR PREPARING HIGH-PURITY (R)-9-[2-(PHOSPHONOMETHOXY)PROPYL]ADENINE|
The present invention relates to a method for preparing high-purity (R)-9-[2-(phosphonomethoxy)propyl]adenine (PMPA). Since (diethoxyphosphoryl)methyl naphthalene-1-sulfonate or (diethoxyphosphoryl)methyl naphthalene-2-sulfonate, which has high purity due to an easy reaction process and fewer impurities generated in the reaction, is used as an intermediate, high-purity PMPA can be prepared. In addition, since the PMPA prepared by the method of the present invention has very high purity, tenofovir diisopropyl and acid adduct salts thereof can be prepared at high purity by using the PMPA, and thus the PMPA is very advantageous in producing high-quality raw material medicines.