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1. (WO2016052928) ALPHA-AMINOAMIDE DERIVATIVE COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2016/052928 International Application No.: PCT/KR2015/010104
Publication Date: 07.04.2016 International Filing Date: 24.09.2015
IPC:
C07C 237/20 (2006.01) ,C07C 237/04 (2006.01) ,C07C 231/12 (2006.01) ,C07C 309/04 (2006.01) ,A61K 31/16 (2006.01) ,A61K 31/167 (2006.01)
Applicants: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY[KR/KR]; 5, Hwarang-ro 14-gil Seongbuk-gu Seoul 02792, KR
Inventors: PARK, Ki Duk; KR
LEE, Changjoon Justin; KR
KIM, Dong Jin; KR
PAE, Ae Nim; KR
CHOO, Hyun Ah; KR
MIN, Sun Joon; KR
KANG, Yong Koo; KR
KIM, Yun Kyung; KR
SONG, Hyo Jung; KR
CHOI, Ji Won; KR
NAM, Min Ho; KR
HEO, Jun Young; KR
YEON, Seul Ki; KR
JANG, Bo Ko; KR
JU, Eun Ji; KR
JO, Seon Mi; KR
PARK, Jong-Hyun; KR
Agent: CHUNG HYUN PATENT & LAW FIRM; Hanmaum Bldg. 4F., 225, Baumoe-ro Seocho-gu Seoul 06740, KR
Priority Data:
10-2014-013298302.10.2014KR
10-2015-013228118.09.2015KR
Title (EN) ALPHA-AMINOAMIDE DERIVATIVE COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
(FR) COMPOSÉ DÉRIVÉ D'ALPHA-AMINOAMIDE ET COMPOSITION PHARMACEUTIQUE LE COMPRENANT
(KO) 알파-아미노아미드 유도체 화합물 및 이를 포함하는 약학적 조성물
Abstract: front page image
(EN) The present invention relates to an alpha-aminoamide derivative compound and a pharmaceutical composition comprising the same. According to various embodiments of the present invention, provided is a therapeutic agent which can overcome the disadvantages of conventional drugs used as a MAO-B inhibitor and, more specifically, reversibly inhibits MAO-B through a non-covalent bond so as to alleviate or eliminate the side effects of conventional drugs by irreversibly acting via a covalent bond with MAO-B to exhibit a therapeutic effect. Particularly, a new compound may be provided having superior stability and efficacy compared to a conventional reversible MAO-B inhibitor.
(FR) La présente invention concerne un composé dérivé d'alpha-aminoamide et une composition pharmaceutique le comprenant. Selon divers modes de réalisation de la présente invention, l'invention concerne un agent thérapeutique qui peut surmonter les inconvénients des médicaments classiques utilisés comme inhibiteur de la MAO-B, et plus particulièrement, inhiber de manière réversible la MAO-B à travers une liaison non covalente de façon à atténuer ou à éliminer les effets secondaires des médicaments classiques en agissant de manière irréversible par l'intermédiaire d'une liaison covalente avec la MAO-B pour faire preuve d'un effet thérapeutique. En particulier, un nouveau composé peut être proposé, possédant une stabilité et une efficacité supérieures par rapport à un inhibiteur réversible classique de la MAO-B.
(KO) 발명은 알파-아미노아미드 유도체 화합물 및 이를 포함하는 약학적 조성물에 관한 것이다. 본 발명의 여러 구현예에 따르면, MAO-B 저해제로 사용되는 기존 약물의 단점을 극복할 수 있으며, 구체적으로는 MAO-B와 공유결합을 통해 비가역적으로 작용하여 치료 효과를 나타내는 기존 약물의 부작용을 완화 혹은 없앨 수 있도록 비공유 결합을 통해 가역적으로 MAO-B를 억제하는 치료제를 제공할 수 있다. 특히 기존의 가역적 MAO-B 저해제 보다 뛰어난 안정성 및 효능을 갖는 새로운 화합물을 제공할 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)