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1. (WO2016051799) 2-AMINOHYDROQUINONE DERIVATIVE AND TAU AGGREGATION INHIBITOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/051799    International Application No.:    PCT/JP2015/004985
Publication Date: 07.04.2016 International Filing Date: 30.09.2015
IPC:
C07D 211/22 (2006.01), A61K 31/136 (2006.01), A61K 31/402 (2006.01), A61K 31/4453 (2006.01), A61K 31/451 (2006.01), A61K 31/495 (2006.01), A61K 31/496 (2006.01), A61K 31/5377 (2006.01), A61K 31/55 (2006.01), A61P 25/00 (2006.01), A61P 25/28 (2006.01), C07D 211/70 (2006.01), C07D 213/74 (2006.01), C07D 223/04 (2006.01), C07D 295/08 (2006.01), C07D 295/16 (2006.01), C07D 295/20 (2006.01)
Applicants: THE DOSHISHA [JP/JP]; 601, Gembu-cho, Karasuma-Higashi-iru, Imadegawa-dori, Kamigyo-ku, Kyoto-shi, Kyoto 6028580 (JP)
Inventors: MIYASAKA, Tomohiro; (JP).
SUGIMOTO, Hachiro; (JP).
OTA, Tetsuo; (JP).
INOUE, Yoshikazu; (JP).
OE, Yohei; (JP).
IHARA, Yasuo; (JP).
TAKASHIMA, Akihiko; (JP).
SOEDA, Yoshiyuki; (JP).
SHINZAKI, Yuki; (JP)
Agent: MAEDA & PARTNERS; Shin-Daibiru Bldg. 23F, 2-1, Dojimahama 1-chome, Kita-ku, Osaka-shi, Osaka 5300004 (JP)
Priority Data:
2014-203336 01.10.2014 JP
Title (EN) 2-AMINOHYDROQUINONE DERIVATIVE AND TAU AGGREGATION INHIBITOR
(FR) DÉRIVÉ DE 2-AMINOHYDROQUINONE ET INHIBITEUR D'AGRÉGATION DE TAU
(JA) 2-アミノヒドロキノン誘導体及びタウ凝集阻害剤
Abstract: front page image
(EN)Provided is a tau aggregation inhibitor which is capable of sufficiently suppressing tau aggregation in cells. The present invention is a compound represented by formula (I) or a salt thereof. This compound is used for at least one application selected from the group consisting of treatment, diagnosis, alleviation of the symptoms, and prophylaxis of tauopathy.
(FR)L'invention concerne un inhibiteur d'agrégation de tau qui est capable de supprimer de façon suffisante l'agrégation de tau dans les cellules. L'invention concerne un composé représenté par la formule (I) ou un sel de celui-ci. Ce composé est utilisé pour au moins une application choisie dans le groupe constitué du traitement, du diagnostic, du soulagement des symptômes, et de la prophylaxie de tauopathie.
(JA) 細胞内のタウ凝集を十分に抑制できるタウ凝集阻害剤を提供する。下記式(I)からなる化合物又はその塩である。この化合物は、タウオパチーの治療、診断、症状の軽減及び予防からなる群から選択される少なくとも一つの用途に使用される。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)