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1. (WO2016051396) PHARMACEUTICAL COMPOSITIONS FOR TREATING EBOLA VIRUS DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/051396    International Application No.:    PCT/IL2015/000043
Publication Date: 07.04.2016 International Filing Date: 20.09.2015
IPC:
A61K 45/06 (2006.01), A61K 31/7076 (2006.01), A61K 31/52 (2006.01), C07H 19/167 (2006.01)
Applicants: VECHT-LIFSHITZ, Susan Eve [IL/IL]; (IL)
Inventors: VECHT-LIFSHITZ, Susan Eve; (IL)
Agent: LIFSHITZ, Susan; I.P. Israel Patents Ltd. P.O. Box 45376 Jerusalem (IL)
Priority Data:
62/057,268 30.09.2014 US
62/079,136 13.11.2014 US
Title (EN) PHARMACEUTICAL COMPOSITIONS FOR TREATING EBOLA VIRUS DISEASE
(FR) COMPOSITIONS PHARMACEUTIQUES POUR LE TRAITEMENT DE LA MALADIE DU VIRUS EBOLA
Abstract: front page image
(EN)The present invention provides compounds and pharmaceutical compositions adapted to reduce a load of an RNA virus by at least 50%, the virus causing a pathogenic disease in a mammalian subject, the compound adapted to inhibit the formation of S-adenosyl methionine (SAM) in the virus, the compound being a DOTIL inhibitor, wherein the compound has a molecular weight of less than 1000, and a therapeutic index (TI= ED50/LD50) greater than 30 in the mammalian subject.
(FR)La présente invention concerne des composés et des compositions pharmaceutiques conçus pour réduire une charge d'un virus à ARN d'au moins 50 %, ledit virus provoquant une maladie pathogène chez un sujet mammifère. Ledit composé est conçu pour inhiber la formation de S-adénosyl méthionine (SAM) dans le virus. En outre, ledit composé est un inhibiteur DOTIL. Par ailleurs, le composé possède un poids moléculaire inférieur à 1000, et un indice thérapeutique (IT = ED50/LD50) supérieur à 30 dans le sujet mammifère.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)