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1. (WO2016051340) A FUSION PROTEIN, A NANOPARTICLE COMPOSED BY A PLURALITY OF MONOMERS OF SAID FUSION PROTEIN, AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/051340    International Application No.:    PCT/IB2015/057448
Publication Date: 07.04.2016 International Filing Date: 29.09.2015
Chapter 2 Demand Filed:    19.07.2016    
IPC:
B82Y 5/00 (2011.01)
Applicants: THENA BIOTECH S.R.L. [IT/IT]; Via Ufente 20 04100 Latina (IT)
Inventors: CECI, Pierpaolo; (IT).
FALVO, Elisabetta; (IT)
Agent: DI GIOVINE, Paolo; (IT)
Priority Data:
TO2014A000779 30.09.2014 IT
Title (EN) A FUSION PROTEIN, A NANOPARTICLE COMPOSED BY A PLURALITY OF MONOMERS OF SAID FUSION PROTEIN, AND USES THEREOF
(FR) PROTÉINE DE FUSION, NANOPARTICULE CONSTITUÉE PAR UNE PLURALITÉ DE MONOMÈRES DE LADITE PROTÉINE DE FUSION, ET LEURS UTILISATIONS
Abstract: front page image
(EN)A fusion protein based on the heavy chain of human ferritin is described, which includes at the N terminus of the protein at least one metalloproteinase cleavage sequence and a PAS polypeptide that acts as a masking polymer that increases the protein-drug stability, as well as a nanoparticle composed of multiple monomers of said fusion protein, a nucleic acid encoding for said fusion protein, and diagnostic and therapeutic applications thereof.
(FR)La présente invention concerne une protéine de fusion basée sur la chaîne lourde de la ferritine humaine, qui comprend au niveau de l'extrémité N-terminale de la protéine au moins une séquence de clivage de la métalloprotéinase et un polypeptide PAS qui agit comme polymère de masquage qui augmente la stabilité protéine-médicament, ainsi qu'une nanoparticule composée de plusieurs monomères de ladite protéine de fusion, un acide nucléique codant pour ladite protéine de fusion, et des applications diagnostiques et thérapeutiques de ceux-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: Italian (IT)