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1. (WO2016050630) ANTIBODY BINDING A LINEAR EPITOPE OF HUMAN P53 AND DIAGNOSTIC APPLICATIONS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2016/050630 International Application No.: PCT/EP2015/072094
Publication Date: 07.04.2016 International Filing Date: 25.09.2015
IPC:
C07K 16/32 (2006.01) ,G01N 33/50 (2006.01)
Applicants: DIADEM S.R.L.[IT/IT]; Via XX Settembre, 14/A I-25124 Brescia (BS), IT
Inventors: MEMO, Maurizio; IT
UBERTI, Daniela Letizia; IT
Agent: MITTLER, Andrea; IT
Priority Data:
TO2014A00077630.09.2014IT
Title (EN) ANTIBODY BINDING A LINEAR EPITOPE OF HUMAN P53 AND DIAGNOSTIC APPLICATIONS THEREOF
(FR) ANTICORPS SE LIANT À UN ÉPITOPE LINÉAIRE DE LA P53 HUMAINE ET SES APPLICATIONS DIAGNOSTIQUES
Abstract: front page image
(EN) The invention relates to an anti-human p53 antibody suitable for specifically binding a linear epitope which is exposed only in a conformationally altered isoform of the characteristic p53 protein of patients with Alzheimer's disease or prone to develop Alzheimer's disease or cognitive impairment during ageing. Methods and diagnostic and prognostic kits are also described.
(FR) L'invention concerne un anticorps anti-p53 humain apte à se lier spécifiquement à un épitope linéaire qui est exposé uniquement dans une isoforme à conformation modifiée de la protéine p53, caractéristique de patients atteints de la maladie d'Alzheimer ou susceptibles de développer la maladie d'Alzheimer ou une déficience cognitive au cours du vieillissement. L'invention concerne également des procédés et des kits de diagnostic et de pronostic.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)