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|1. (WO2016050209) HETEROFUNCTIONALIZED POLYETHYLENE GLYCOL DERIVATIVE, PREPARATION METHOD, AND BIO-RELATED SUBSTANCE|
|Applicants:||XIAMEN SINOPEG BIOTECH CO., LTD.
|Title:||HETEROFUNCTIONALIZED POLYETHYLENE GLYCOL DERIVATIVE, PREPARATION METHOD, AND BIO-RELATED SUBSTANCE|
Disclosed are a heterofunctionalized polyethylene glycol derivative (formula I), a preparation method, and a bio-related substance modified by the derivative. The derivative has a Y-shaped structure, which is a branched central structure Uc constituted by a trivalent group U and linking groups L1, L2, and L3, and is provided with two different functional groups F1 and F2; three PEG chains respectively have the degrees of polymerization of n1, n2, and n3 and discretely have either polydispersity or monodispersity; extremities of the PEG chains respectively are connected to at least one functional group via branching groups G1, G2, and G3; when g1, g2, and g3 are 1, the extremities are provided with multiple active sites; the numbers of repeating units of bivalent linking groups L4 and L6 are p1, p2, and p3; and, any one of the link groups or any linking group formed with an adjacent heteroatom group can either remain stable or be degraded. The functionalized polyethylene glycol is flexible and diverse in terms of branch structures and the lengths of branching arms, has various parameters and performance indicators that are adjustable and easy to control, and has a broad applicability.