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1. (WO2016050209) HETEROFUNCTIONALIZED POLYETHYLENE GLYCOL DERIVATIVE, PREPARATION METHOD, AND BIO-RELATED SUBSTANCE

Pub. No.:    WO/2016/050209    International Application No.:    PCT/CN2015/091178
Publication Date: Fri Apr 08 01:59:59 CEST 2016 International Filing Date: Thu Oct 01 01:59:59 CEST 2015
IPC: C08G 65/333
C08G 65/332
C08G 65/334
C08G 65/331
C08G 65/336
C08G 65/28
C08G 65/329
A61K 47/48
Applicants: XIAMEN SINOPEG BIOTECH CO., LTD.
厦门赛诺邦格生物科技股份有限公司
Inventors: WENG, Wengui
翁文桂
LIU, Chao
刘超
YAN, Ce
闫策
WU, Shaofeng
吴少峰
LIAO, Jincheng
廖金城
ZHOU, Chun
周纯
Title: HETEROFUNCTIONALIZED POLYETHYLENE GLYCOL DERIVATIVE, PREPARATION METHOD, AND BIO-RELATED SUBSTANCE
Abstract:
Disclosed are a heterofunctionalized polyethylene glycol derivative (formula I), a preparation method, and a bio-related substance modified by the derivative. The derivative has a Y-shaped structure, which is a branched central structure Uc constituted by a trivalent group U and linking groups L1, L2, and L3, and is provided with two different functional groups F1 and F2; three PEG chains respectively have the degrees of polymerization of n1, n2, and n3 and discretely have either polydispersity or monodispersity; extremities of the PEG chains respectively are connected to at least one functional group via branching groups G1, G2, and G3; when g1, g2, and g3 are 1, the extremities are provided with multiple active sites; the numbers of repeating units of bivalent linking groups L4 and L6 are p1, p2, and p3; and, any one of the link groups or any linking group formed with an adjacent heteroatom group can either remain stable or be degraded. The functionalized polyethylene glycol is flexible and diverse in terms of branch structures and the lengths of branching arms, has various parameters and performance indicators that are adjustable and easy to control, and has a broad applicability.