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1. (WO2016050199) MEDICAMENT DESIGN POCKET OF ORNITHINE DECARBOXYLASE AND APPLICATION OF MEDICAMENT DESIGN POCKET
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2016/050199 International Application No.: PCT/CN2015/091044
Publication Date: 07.04.2016 International Filing Date: 29.09.2015
IPC:
C12Q 1/527 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
527
involving lyase
Applicants:
三峡大学 CHINA THREE GORGES UNIVERSITY [CN/CN]; 中国湖北省宜昌市 西陵区大学路8号 No.8, University Road, Xiling District Yichang, Hubei 443002, CN
Inventors:
刘森 LIU, Sen; CN
Agent:
宜昌市三峡专利事务所 YICHANG THREE GORGES PATENT OFFICE; 中国湖北省宜昌市西陵区 云集路21-3号 No.21-3 Yunji Road, Xiling District Yichang, Hubei 443000, CN
Priority Data:
201410522192.230.09.2014CN
201410524065.630.09.2014CN
201410524151.730.09.2014CN
201410525191.330.09.2014CN
201410525202.830.09.2014CN
Title (EN) MEDICAMENT DESIGN POCKET OF ORNITHINE DECARBOXYLASE AND APPLICATION OF MEDICAMENT DESIGN POCKET
(FR) POCHE D'ORNITHINE DÉCARBOXYLASE POUR LA CONCEPTION DE MÉDICAMENTS ET SON APPLICATION
(ZH) 一种鸟氨酸脱羧酶的药物设计口袋及其应用
Abstract:
(EN) Disclosed is a medicament design pocket of ornithine decarboxylase. On the basis of a crystal structure of human ornithine decarboxylase (ODC), the area of a binding site of putrescine and pyridoxal phosphate (PLP) ligands on a homodimer interface of the ornithine decarboxylase (ODC) is a medicament pocket. The medicament pocket can be used for screening, designing or transforming an inhibitor of human ornithine decarboxylase or non-human ornithine decarboxylase, or screening, designing or transforming an inhibitor of a protein highly homogenous with the binding site of putrescine and pyridoxal phosphate on the homodimer interface of the ornithine decarboxylase.
(FR) Cette invention concerne une poche d'ornithine décarboxylase pour la conception de médicaments. Sur la base d'une structure cristalline d'ornithine décarboxylase (ODC) humaine, la surface d'un site de liaison de ligands de putrescéine et de phosphate pyridoxal (PLP) sur l'interface homodimère de l'ornithine décarboxylase (ODC) devient une poche à médicaments. La poche à médicaments peut être utilisée pour cribler, concevoir ou transformer un inhibiteur d'ornithine décarboxylase humaine ou pour cribler, concevoir ou transformer un inhibiteur d'une protéine très homogène avec le site de liaison de la putrescéine et du phosphate pyridoxal sur l'interface homodimère de l'ornithine décarboxylase.
(ZH) 本发明公开了一种鸟氨酸脱羧酶的药物设计口袋。以人源鸟氨酸脱羧酶(ODC)的晶体结构为基础,鸟氨酸脱羧酶(ODC)同源二聚体界面上的腐胺和磷酸吡哆醛(PLP)配体的结合位点所在区域为药物口袋。所述药物口袋可用于筛选、设计或改造人源或非人源鸟氨酸脱羧酶的抑制剂,或与鸟氨酸脱羧酶同源二聚体界面上的腐胺和磷酸吡哆醛结合位点高度同源的蛋白的抑制剂。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)