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1. (WO2016050110) BIOMARKERS FOR RHEUMATOID ARTHRITIS AND USAGE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2016/050110 International Application No.: PCT/CN2015/083488
Publication Date: 07.04.2016 International Filing Date: 07.07.2015
IPC:
C12N 1/20 (2006.01) ,C12Q 1/04 (2006.01) ,C12Q 1/68 (2006.01) ,C12M 1/00 (2006.01) ,A61K 35/74 (2015.01) ,A61P 3/04 (2006.01) ,A61P 3/10 (2006.01)
Applicants: BGI SHENZHEN[CN/CN]; Main Building, Beishan Industrial Zone, Yantian District Shenzhen, Guangdong 518083, CN
Inventors: FENG, Qiang; CN
ZHANG, Dongya; CN
JIA, Huijue; CN
WANG, Donghui; CN
WANG, Jun; CN
Agent: TSINGYIHUA INTELLECTUAL PROPERTY LLC; Room 301, Trade Building, Zhaolanyuan, Tsinghua University, Qinghuayuan, Haidian District Beijing 100084, CN
Priority Data:
PCT/CN2014/08806030.09.2014CN
PCT/CN2014/08806830.09.2014CN
PCT/CN2014/08806930.09.2014CN
Title (EN) BIOMARKERS FOR RHEUMATOID ARTHRITIS AND USAGE THEREOF
(FR) BIOMARQUEURS POUR LA POLYARTHRITE RHUMATOÏDE ET LEUR UTILISATION
Abstract: front page image
(EN) Biomarkers and methods for predicting risk of a disease in particular RA are provided. Sequences of DNA are obtained. The DNA may be extracted from a sample that is collected from a subject. A relative abundance of a biomarker is then calculated based on the sequences of the DNA. The biomarker comprises a DNA sequence in a genome of Lactobacillus salivarius. A probability of the subject having the disease is obtained based on the relative abundance.
(FR) La présente invention concerne des biomarqueurs et des méthodes permettant de prédire un risque de développer une maladie, en particulier une polyarthrite rhumatoïde. Des séquences d'ADN sont obtenues. L'ADN peut être extrait d'un échantillon qui est prélevé sur un sujet. L'abondance relative d'un biomarqueur est ensuite calculée en se basant sur les séquences de l'ADN. Le biomarqueur comprend une séquence d'ADN dans un génome de Lactobacillus salivarius. Une probabilité que le sujet soit atteint de la maladie est obtenue en se basant sur l'abondance relative.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)