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|1. (WO2016049884) CONOTOXIN POLYPEPTIDE Κ-CPTX-BT105, AND METHOD FOR PREPARATION THEREOF AND APPLICATION THEREOF|
|Applicants:||BGI SHENZHEN CO., LIMITED
|Title:||CONOTOXIN POLYPEPTIDE Κ-CPTX-BT105, AND METHOD FOR PREPARATION THEREOF AND APPLICATION THEREOF|
Provided are a conotoxin polypeptide κ-CPTx-bt105, a method for preparation thereof, and an application thereof. The conotoxin polypeptide consists of 16 amino acids, has a molecular weight of 1626.62 daltons, and has the full sequence GICCVDDTCTTHSGCL. The conotoxin polypeptide has a potassium ion channel current-suppression effect and an analgesic effect, and may be used for drug development and clinical applications to treat pain, epilepsy, stroke, convulsions, muscle relaxation, Parkinson's disease, Alzheimer's disease, depression, addiction, cardiovascular disease, cancer, inflammation, and other diseases.