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1. (WO2016049884) CONOTOXIN POLYPEPTIDE Κ-CPTX-BT105, AND METHOD FOR PREPARATION THEREOF AND APPLICATION THEREOF

Pub. No.:    WO/2016/049884    International Application No.:    PCT/CN2014/087997
Publication Date: Fri Apr 08 01:59:59 CEST 2016 International Filing Date: Wed Oct 01 01:59:59 CEST 2014
IPC: C07K 7/08
C07K 1/18
C07K 1/14
A61P 25/08
A61P 29/00
A61P 1/06
A61P 21/00
A61P 25/16
A61P 25/28
A61P 25/24
A61P 9/00
A61P 35/00
A61P 25/30
Applicants: BGI SHENZHEN CO., LIMITED
深圳华大基因科技有限公司
Inventors: LIN, Zhilong
林志龙
WEN, Bo
闻博
TONG, Ting
童婷
LIU, Jie
刘杰
DU, Chaoqin
杜朝钦
MO, Fen
莫芬
PENG, Chao
彭超
SHI, Qiong
石琼
Title: CONOTOXIN POLYPEPTIDE Κ-CPTX-BT105, AND METHOD FOR PREPARATION THEREOF AND APPLICATION THEREOF
Abstract:
Provided are a conotoxin polypeptide κ-CPTx-bt105, a method for preparation thereof, and an application thereof. The conotoxin polypeptide consists of 16 amino acids, has a molecular weight of 1626.62 daltons, and has the full sequence GICCVDDTCTTHSGCL. The conotoxin polypeptide has a potassium ion channel current-suppression effect and an analgesic effect, and may be used for drug development and clinical applications to treat pain, epilepsy, stroke, convulsions, muscle relaxation, Parkinson's disease, Alzheimer's disease, depression, addiction, cardiovascular disease, cancer, inflammation, and other diseases.