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1. (WO2016049829) CHRONIC HEART DISEASE PATIENT SPECIFIC BIOMARKER COMPOSITION AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2016/049829 International Application No.: PCT/CN2014/087852
Publication Date: 07.04.2016 International Filing Date: 30.09.2014
IPC:
G01N 30/02 (2006.01) ,G01N 30/62 (2006.01) ,G01N 33/48 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30
Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02
Column chromatography
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30
Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02
Column chromatography
62
Detectors specially adapted therefor
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
Applicants:
深圳华大基因科技有限公司 BGI SHENZHEN CO.,LIMITED [CN/CN]; 中国广东省深圳市 盐田区北山路146号北山工业区综合楼11F-3 Main Building 11f-3, Beishan Industrial Zone Beishan Road 146, Yantian District Shenzhen, Guangdong 518083, CN
深圳华大基因研究院 BGI SHENZHEN [CN/CN]; 中国广东省深圳市 盐田区北山工业区综合楼 Main Building, Beishan Industrial Zone Yantian District Shenzhen, Guangdong 518083, CN
Inventors:
冯强 FENG, Qiang; CN
刘志鹏 LIU, Zhipeng; CN
孟楠 MENG, Nan; CN
王俊 WANG, Jun; CN
Agent:
中国国际贸易促进委员会专利商标事务所 CCPIT PATENT AND TRADEMARK LAW OFFICE; 中国北京市 西城区阜成门外大街2号万通新世界广场8层 8th Floor, Vantone New World Plaza 2 Fuchengmenwai Street, Xicheng District Beijing 100037, CN
Priority Data:
Title (EN) CHRONIC HEART DISEASE PATIENT SPECIFIC BIOMARKER COMPOSITION AND USE THEREOF
(FR) COMPOSITION DE BIOMARQUEUR SPÉCIFIQUE D'UN PATIENT ATTEINT D'UNE MALADIE CARDIAQUE CHRONIQUE ET UTILISATION ASSOCIÉE
(ZH) 冠心病患者特异性生物标志组合物及其用途
Abstract:
(EN) Provided is a disease specific metabolite profile, in particular a biomarker composition obtained via chronic heart disease patient urine specific metabolite profile screening. Also provided are a use of the biomarker composition for chronic heart disease risk assessment, diagnosis, early diagnosis and pathological staging, and a chronic heart disease risk assessment, diagnosis, early diagnosis and pathological staging method. The biomarker composition may be used for the early diagnosis of chronic heart disease, and has high sensitivity, good specificity and favourable application prospects.
(FR) L'invention concerne un profil de métabolite spécifique à une maladie, en particulier une composition de biomarqueur obtenue par l'intermédiaire d'un criblage de profil de métabolite spécifique à l'urine d'un patient atteint d'une maladie cardiaque chronique. L'invention concerne également une utilisation de la composition de biomarqueur pour l'évaluation du risque, le diagnostic, le diagnostic précoce et la stadification pathologique d'une maladie cardiaque chronique, ainsi qu'un procédé pour l'évaluation du risque, le diagnostic, le diagnostic précoce et la stadification pathologique d'une maladie cardiaque chronique. La composition de biomarqueur peut être utilisée pour le diagnostic précoce d'une maladie cardiaque chronique, et présente une sensibilité élevée, une bonne spécificité et de bonne perspectives d'application.
(ZH) 提供一种疾病特异性代谢物谱,特别是涉及由冠心病患者尿液特异性代谢物谱筛选得到的生物标志组合物。以及所述生物标志组合物用于冠心病的患病风险评估、诊断、早期诊断以及病理分期的用途,以及冠心病的患病风险评估、诊断、早期诊断以及病理分期方法。提供的生物标志组合物可用于早期诊断冠心病,并且灵敏度高、特异性好,具有良好的应用前景。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)