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1. (WO2016049770) MARKERS FOR MOOD DISORDERS

Pub. No.:    WO/2016/049770    International Application No.:    PCT/CA2015/050990
Publication Date: Fri Apr 08 01:59:59 CEST 2016 International Filing Date: Fri Oct 02 01:59:59 CEST 2015
IPC: C12N 9/02
C07K 16/40
C07K 7/06
C07K 7/08
C12Q 1/26
C12Q 1/37
C40B 30/04
C40B 40/10
G01N 33/48
G01N 33/483
G01N 33/68
Applicants: CENTRE FOR ADDICTION AND MENTAL HEALTH
Inventors: MEYER, Jeffrey
EVANS, Ken
CHEN, Jian
ACKLOO, Suzanne
DHARSEE, Moyez
Title: MARKERS FOR MOOD DISORDERS
Abstract:
Disclosed is a method for diagnosing a mood disorder or susceptibility to a mood disorder, including depressive disorders and bipolar disorder, from a biological sample taken from a subject. The method includes detecting markers of monoamine oxidase-A (MAO-A) in the biological sample; determining MAO-A concentration from the markers; and correlating the MAO-A concentration in the biological sample to a control group which does not have a mood disorder in order to diagnose or determine susceptibility to the mood disorder in the subject. Also disclosed is a method of detecting peripheral markers of MAO-A for the diagnosis of a mood disorder or susceptibility to a mood disorder. Also provided are polypeptide markers.