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1. (WO2016046419) NEW IMMUNOSTIMULATORY COMPOUNDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2016/046419 International Application No.: PCT/EP2015/072292
Publication Date: 31.03.2016 International Filing Date: 28.09.2015
IPC:
A61K 31/683 (2006.01) ,A61K 31/7034 (2006.01) ,C07H 15/20 (2006.01) ,C07F 9/10 (2006.01) ,A61P 35/00 (2006.01) ,A61P 33/02 (2006.01) ,A61K 35/15 (2015.01) ,A61P 33/00 (2006.01) ,A61P 31/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
683
Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7028
Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
7034
attached to a carbocyclic compound, e.g. phloridzin
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15
Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
20
Carbocyclic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
06
without P-C bonds
08
Esters of oxyacids of phosphorus
09
Esters of phosphoric acids
10
Phosphatides, e.g. lecithin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33
Antiparasitic agents
02
Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
[IPC code unknown for A61K 35/15]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33
Antiparasitic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Applicants:
BERNHARD-NOCHT-INSTITUT FÜR TROPENMEDIZIN [DE/DE]; Bernhard-Nocht-Straße 74 20359 Hamburg, DE
FORSCHUNGSZENTRUM BORSTEL [DE/DE]; Leibniz-institut Für Medizin Und Biowissenschaften Parkallee 1-40 23765 Borstel, DE
Inventors:
LOTTER, Hannelore; DE
BERNIN, Hannah; DE
TANNICH, Egbert; DE
GONZALEZ-ROLDAN, Nestor; DE
FUJIMOTO, Yukari; JP
FUKASE, Koichi; JP
Agent:
UEXKÜLL & STOLBERG; Beselerstr. 4 D-22607 Hamburg, DE
Priority Data:
14186723.428.09.2014EP
Title (EN) NEW IMMUNOSTIMULATORY COMPOUNDS
(FR) NOUVEAUX COMPOSÉS IMMUNOSTIMULANTS
Abstract:
(EN) The present invention relates to novel immunostimulatory molecules which are derived from the intestinal protozoan Entamoeba histolytica.The compounds have been found to be useful for enhancing and/or inducing an immune response in a subject in need thereof. Specifically, the compounds have been found to be useful for the treatment of cancer diseases, such as breast cancer, and parasitic diseases, such as leishmaniasis. The invention also provides pharmaceutical compositions comprising the novel compounds.
(FR) La présente invention concerne de nouvelles molécules immunostimulantes qui dérivent du protozoaire intestinal Entamoeba histolytica.Les composés se sont avérés utiles pour renforcer et/ou induire une réponse immunitaire chez un sujet en ayant besoin. Spécifiquement, les composés se sont avérés utiles pour le traitement de maladies cancéreuses, telles que le cancer du sein, et de maladies parasitaires, telles que la leishmaniose. La présente invention concerne également des compositions pharmaceutiques comprenant les nouveaux composés.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP3197461US20170298083IN201747014564BR112017006177RU2017114429