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1. WO2016028914 - COMPOSITONS AND METHODS FOR CARTILAGE DEFECT REPAIR USING A RHAMM-MIMETIC PEPTIDE

Publication Number WO/2016/028914
Publication Date 25.02.2016
International Application No. PCT/US2015/045934
International Filing Date 19.08.2015
IPC
A61K 31/728 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
726Glycosaminoglycans, i.e. mucopolysaccharides
728Hyaluronic acid
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
A61P 19/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
CPC
A61K 31/728
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
726Glycosaminoglycans, i.e. mucopolysaccharides
728Hyaluronic acid
A61K 35/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
A61K 38/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
10Peptides having 12 to 20 amino acids
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
C07K 14/70585
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
70585CD44
C07K 14/70596
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
70596Molecules with a "CD"-designation not provided for elsewhere
Applicants
  • NEW YORK UNIVERSITY [US]/[US]
  • LONDON HEALTH SCIENCES CENTRE RESEARCH INC. [CA]/[CA]
Inventors
  • COWMAN, Mary, K.
  • KIRSCH, Thorsten
  • STRAUSS, Eric, J.
  • TURLEY, Eva, Ann
  • TOELG, Cornelia
  • LUYT, Leonard, G.
Agents
  • WATT, Rachel, S.
Priority Data
62/039,15019.08.2014US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITONS AND METHODS FOR CARTILAGE DEFECT REPAIR USING A RHAMM-MIMETIC PEPTIDE
(FR) COMPOSITIONS ET PROCÉDÉS POUR LA RÉPARATION DE DÉFAUTS DU CARTILAGE À L'AIDE D'UN PEPTIDE MIMÉTIQUE DU RÉCEPTEUR POUR LA MOTILITÉ MÉDIÉE PAR L'ACIDE HYALURONIQUE (RHAMM)
Abstract
(EN)
Provided are methods and compositions for cartilage repair. The method involves performing a surgical procedure at the site of a cartilage defect and administering a composition comprising a receptor for hyaluronan mediated motility (RHAMM)-mimetic peptide, and a high molecular weight hyaluronan.
(FR)
L'invention concerne des procédés et des compositions pour la réparation du cartilage. Le procédé consiste à réaliser une intervention chirurgicale au niveau du site d'un défaut du cartilage et à administrer une composition comprenant un peptide mimétique du récepteur pour la motilité médiée par l'acide hyaluronique (RHAMM), et un acide hyaluronique de masse moléculaire élevée.
Also published as
Latest bibliographic data on file with the International Bureau