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1. (WO2016027276) ACTIVE METABOLITE OF 1-[(2-BROMOPHENYL) SULFONYL]-5-METHOXY-3- [(4-METHYL-1-PIPERAZINYL) METHYL]-1H-INDOLE DIMESYLATE MONOHYDRATE AND DIMESYLATE DIHYDRATE SALT OF ACTIVE METABOLITE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2016/027276 International Application No.: PCT/IN2014/000667
Publication Date: 25.02.2016 International Filing Date: 20.10.2014
Chapter 2 Demand Filed: 08.05.2015
IPC:
A61K 31/4045 (2006.01) ,A61P 25/00 (2006.01) ,C07D 209/14 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
404
Indoles, e.g. pindolol
4045
Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
04
Indoles; Hydrogenated indoles
10
with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
14
Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Applicants:
SUVEN LIFE SCIENCES LIMITED [IN/IN]; Serene Chambers, Road - 5, Avenue -7 Banjara Hills Hyderabad 500034 Andhra Pradesh, IN
Inventors:
NIROGI, Ramakrishna; IN
KAMBHAMPATI, Ramasastri; IN
SHINDE, Anil Karbhari; IN
JASTI, Venkateswarlu; IN
Agent:
SUBRAMANIAM, Hariharan; Subramaniam & Associates Central Square, Suite-328 Plaza III, 20 Manoharlal Khurana Marg, Bara Hindu Rao (off Rani Jhansi Road) Delhi 110 048, IN
Priority Data:
4011/CHE/201416.08.2014IN
Title (EN) ACTIVE METABOLITE OF 1-[(2-BROMOPHENYL) SULFONYL]-5-METHOXY-3- [(4-METHYL-1-PIPERAZINYL) METHYL]-1H-INDOLE DIMESYLATE MONOHYDRATE AND DIMESYLATE DIHYDRATE SALT OF ACTIVE METABOLITE
(FR) MÉTABOLITE ACTIF DU 1-[(2-BROMOPHÉNYL)SULFONYL]-5-MÉTHOXY-3-[(4-MÉTHYL-1-PIPÉRAZINYLE)MÉTHYL]-1H-INDOLE DIMÉSYLATE MONOHYDRATÉ ET SEL DIMÉSYLATE DIHYDRATÉ DU MÉTABOLITE ACTIF
Abstract:
(EN) The present invention is directed to active metabolite of 1-[(2- bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole dimesylate monohydrate having the following structure The present invention is also directed to dimesylate dihydrate salt of formula (I) having the following structure The compounds of formula (I) and formula (II) are useful in the treatment of various disorders that are related to 5-HT6 receptor antagonist.
(FR) La présente invention concerne un métabolite actif du 1-[(2-bromophényl)sulfonyl]-5-méthoxy-3-[(4-méthyl-1-pipérazinyle)méthyl]-1H-indole dimésylate monohydraté ayant la structure suivante. La présente invention se rapporte également au sel dimésylate dihydraté de formule (I) ayant la structure suivante. Les composés de formule (I) et de formule (II) sont utilisés pour traiter différents troubles qui sont associés à un antagoniste du récepteur 5-HT6.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA2957497AU2014404000KR1020170031237IL250411CN106794170EP3180001
US20170273944JP2017525762EA201790396BR112017002921TH1701000767AES2715113