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1. WO2016026401 - METHOD FOR ENHANCING HPV EPITOPE PEPTIDE IMMUNOGENICITY, VIROID PARTICLE, PARTICLE PREPARATION METHOD AND APPLICATION

Publication Number WO/2016/026401
Publication Date 25.02.2016
International Application No. PCT/CN2015/086636
International Filing Date 11.08.2015
IPC
C12N 15/70 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
70Vectors or expression systems specially adapted for E. coli
C12N 7/04 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
04Inactivation or attenuation; Producing viral sub-units
A61K 39/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61P 31/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
CPC
A61K 2039/5258
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5258Virus-like particles
A61K 2039/575
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
57characterised by the type of response, e.g. Th1, Th2
575humoral response
A61K 2039/6075
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
60characteristics by the carrier linked to the antigen
6031Proteins
6075Viral proteins
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61P 31/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
C07K 14/025
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
01DNA viruses
025Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
Applicants
  • 天津康希诺生物技术有限公司 TIANJIN CANSINO BIOTECHNOLOGY INC. [CN]/[CN]
Inventors
  • 邵忠琦 SHAO, Zhongqi
  • 李军强 LI, Junqiang
  • 蒋蓉 JIANG, Rong
  • 杨鸣鸣 YANG, Mingming
  • 朱涛 ZHU, Tao
  • 毛慧华 MAO, Helen Huihua
  • 宇学峰 YU, Xuefeng
Agents
  • 天津市三利专利商标代理有限公司 TIANJIN SANLI PATENT&TRADEMARK AGENCY CO., LTD.
Priority Data
201410419379.X22.08.2014CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) METHOD FOR ENHANCING HPV EPITOPE PEPTIDE IMMUNOGENICITY, VIROID PARTICLE, PARTICLE PREPARATION METHOD AND APPLICATION
(FR) MÉTHODE POUR AMÉLIORER L'IMMUNOGÉNICITÉ D'UN ÉPITOPE PEPTIDIQUE DU VPH, PARTICULE VIROÏDE, MÉTHODE DE PRÉPARATION ET APPLICATION
(ZH) 增强HPV抗原表位肽免疫原性的方法及类病毒颗粒、颗粒制备方法与应用
Abstract
(EN)
Disclosed is a method for enhancing HPV epitope peptide immunogenicity, which comprises: assembling an HPV antigen gene on an HBc gene, allowing the integrated gene to express fusion protein by an exogenous expression system, allowing the fusion protein to automatically assemble to form a viroid particle VLP, and allowing the VLP surface to exhibit more than one copy of the HPV antigen, so as to obtain HBc-HPV VLP.
(FR)
L'invention concerne une méthode pour améliorer l'immunogénicité d'un épitope peptidique du VPH, qui consiste à : fusionner un gène d'un antigène du VPH avec le gène de HBc, à permettre au gène de fusion d'exprimer une protéine de fusion via un système d'expression exogène, à permettre à la protéine de fusion de s'auto-assembler pour former une particule viroïde VLP, et à permettre la présentation en surface de VLP de plus d'une copie de l'antigène du VPH, de manière à obtenir une VLP HBc-VPH.
(ZH)
本发明公开了一种增强HPV抗原表位肽免疫原性的方法,把HPV抗原基因组装到HBc的基因上,将整合之后的基因通过外源表达系统表达融合蛋白,融合蛋白将自动组装形成类病毒颗粒VLP,且所述VLP表面展示多于一个拷贝的HPV抗原,得到HBc-HPV VLP。
Also published as
Latest bibliographic data on file with the International Bureau