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1. WO2016024855 - PHARMACEUTICAL COMPOSITION IN IVERMECTIN EMULGEL FOR VETERINARY USE AS A PROMOTER SYSTEM AND BIO-ADHESIVE IN ANTIPARASITIC TREATMENT, AND METHOD FOR THE PRODUCTION THEREOF

Publication Number WO/2016/024855
Publication Date 18.02.2016
International Application No. PCT/MX2015/000114
International Filing Date 12.08.2015
IPC
A61K 9/107 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
107Emulsions
A61K 31/365 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
365Lactones
A01N 25/04 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
25Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
02containing liquids as carriers, diluents or solvents
04Dispersions or gels
CPC
A61K 31/7048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7048having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin ; digitoxin or digoxin
A61K 47/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen, ; e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
A61K 47/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
16containing nitrogen, ; e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
A61K 47/26
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 47/32
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers ; , poly(meth)acrylates, or polyvinyl pyrrolidone
A61K 47/44
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
Applicants
  • UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO [MX]/[MX]
Inventors
  • QUINTANAR GUERRERO, David
  • MARTÍNEZ LABAT, Juan Pablo
  • MENDOZA ELVIRA, Susana Elisa
  • VIDAL ROMERO, Gustavo
  • TRENADO HERNÁNDEZ, Víctor Andrés
Agents
  • FIGUEROA PÉREZ, Martha
Priority Data
MX/a/2014/00968812.08.2014MX
Publication Language Spanish (ES)
Filing Language Spanish (ES)
Designated States
Title
(EN) PHARMACEUTICAL COMPOSITION IN IVERMECTIN EMULGEL FOR VETERINARY USE AS A PROMOTER SYSTEM AND BIO-ADHESIVE IN ANTIPARASITIC TREATMENT, AND METHOD FOR THE PRODUCTION THEREOF
(ES) COMPOSICIÓN FARMACEUTICA EN EMULGEL DE IVERMECTINA PARA USO VETERINARIO COMO SISTEMA PROMOTOR Y BIOADHESIVO EN EL TRATAMIENTO ANTIPARASITARIO, Y METODO PARA OBTENER LA MISMA
(FR) COMPOSITION PHARMACEUTIQUE EN ÉMULGEL D'IVERMECTINE À USAGE VÉTÉRINAIRE COMME SYSTÈME PROMOTEUR ET BIOADHÉSIF DANS LE TRAITEMENT ANTIPARASITAIRE, ET SON PROCÉDÉ D'OBTENTION
Abstract
(EN)
The invention relates to a pharmaceutical composition comprising: at least one antiparasitic active ingredient for providing the pharmacological therapeutic effect; an agent having bio-adhesive properties that helps to reduces the motility and reproduction of the parasites, increasing the period of time for which the product remains on the skin of the animals; an agent having permeation- or absorption-promoting properties that contributes to increasing the cutaneous permeability of the active ingredient; a surfactant agent that is absorbed in an oil-water interface, and as a result, the molecules of said surfactant agent form a kind of bridge between the polar phase (water) and the non-polar phase (oil), thereby making the transition between both phases less abrupt; an oil which will form the oily phase of the emulsion, and which will incorporate the active ingredient; and a neutralising agent.
(ES)
La presente invención se refiere a una composición farmacéutica que comprende: al menos un principio activo antiparasitario que es el encargado de proveer el efecto terapéutico farmacológico; un agente con propiedades bio-adhesivas que ayuda a reducir la motilidad y reproducción de los parásitos infestantes, aumentando la estancia del producto sobre la piel de los animales; un agente con propiedades promotoras de permeación o absorción que coadyuva a incrementar la permeabilidad cutánea del principio activo; un agente surfactante o tensoactivo, el cual es adsorbido en una interfase aceite-agua, y como consecuencia de ello, las moléculas de dicho agente tensoactivo forman una especie de "puente" entre la fase polar (agua) y la fase no polar (aceite), haciendo así que la transición entre ambas fases sea menos brusca; un aceite que va a formar la fase oleosa de la emulsión y es quien va a incorporar al principio activo; y, un agente neutralizante.
(FR)
La présente invention concerne une composition pharmaceutique qui comprend: au moins un principe actif antiparasitaire qui est chargé d'assurer l'effet thérapeutique pharmacologique; un agent à propriétés bioadhésives qui aide à réduire la mortalité et la reproduction des parasites infestants, augmentant la durée pendant laquelle le produit reste sur la peau des animaux; un agent à propriétés promotrices de perméation ou d'absorption qui aide conjointement à augmenter la perméabilité cutanée du principe actif; un agent surfactant ou tensioactif, lequel est adsorbé dans une interface huile-eau, et par conséquent, les molécules dudit agent tensioactif forment une espèce de "pont" entre la phase polaire (eau) et la phase non polaire (huile), la transition entre les deux phase étant ainsi moins brusque; une huile qui va former la phase huileuse de l'émulsion et qui va intégrer le principe actif; et, un agent neutralisant.
Also published as
Latest bibliographic data on file with the International Bureau