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1. WO2016024114 - MODULAR MICROFLUIDIC DEVICE

Publication Number WO/2016/024114
Publication Date 18.02.2016
International Application No. PCT/GB2015/052334
International Filing Date 12.08.2015
IPC
B01L 3/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
G01N 35/10 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
35Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/-G01N33/148; Handling materials therefor
10Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
CPC
B01L 2200/027
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2200Solutions for specific problems relating to chemical or physical laboratory apparatus
02Adapting objects or devices to another
026Fluid interfacing between devices or objects, e.g. connectors, inlet details
027for microfluidic devices
B01L 2200/028
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2200Solutions for specific problems relating to chemical or physical laboratory apparatus
02Adapting objects or devices to another
028Modular arrangements
B01L 2200/0605
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2200Solutions for specific problems relating to chemical or physical laboratory apparatus
06Fluid handling related problems
0605Metering of fluids
B01L 2200/0631
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2200Solutions for specific problems relating to chemical or physical laboratory apparatus
06Fluid handling related problems
0631Purification arrangements, e.g. solid phase extraction [SPE]
B01L 2300/0681
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2300Additional constructional details
06Auxiliary integrated devices, integrated components
0681Filter
B01L 2400/0487
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2400Moving or stopping fluids
04Moving fluids with specific forces or mechanical means
0475specific mechanical means and fluid pressure
0487fluid pressure, pneumatics
Applicants
  • CAMBSOLV LIMITED [GB]/[GB]
Inventors
  • MALKIN, Hugh
  • HASTINGS, Nicholas James
  • GUTSELL, Graham Scott
  • GEORGE, Ian Morgan
Agents
  • SHARPLES, Andrew
Priority Data
1414247.512.08.2014GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MODULAR MICROFLUIDIC DEVICE
(FR) DISPOSITIF MICROFLUIDIQUE MODULAIRE
Abstract
(EN)
Described is a modular microfluidic device (MMD) for producing an analyte composition from a biological fluid sample, said device comprising: (a) a reagent module (RM) comprising a reagent reservoir containing a reagent and an eluent reservoir containing an eluent, said reagent and eluent reservoirs being coupled to one or more RM microchannels; and (b) a sample preparation module (SPM) comprising a SPM microchannel adapted to couple with the RM microchannel whereby fluid continuity between SPM and RM microchannels is produced on coupling, and: (i) a sample inlet for receiving said biological fluid sample; (ii) an outlet for delivering said analyte composition; (iii) a mixing chamber; (v) a metering chamber; (vi) an eluent chamber; (vii) a valve; (viii) a solid phase extraction element (SPE); and (ix) an aspirator in fluid communication with the sample inlet of the SPM for withdrawing an aliquot of said biological fluid when contained in a sample vessel, said aspirator being operably coupled to a pneumatic fluid level sensor.
(FR)
L'invention concerne un dispositif microfluidique modulaire (MMD) permettant de produire une composition d'analyte à partir d'un échantillon de fluide biologique, ledit dispositif comprenant : (a) un module de réactif (RM) comprenant un réservoir à réactif contenant un réactif et un réservoir à éluant contenant un éluant, lesdits réservoirs à réactif et à éluant étant couplés à au moins un microcanal de RM ; et (b) un module de préparation d'échantillon (SPM) comprenant un microcanal de SPM conçu pour se coupler au microcanal de RM, la continuité fluidique entre les microcanaux de RM et de SPM étant produite lors de l'accouplement, et : (i) une entrée d'échantillon permettant de recevoir ledit échantillon de fluide biologique ; (ii) une sortie permettant de distribuer ladite composition d'analyte ; (iii) une chambre de mélange ; (v) une chambre de dosage ; (vi) une chambre d'éluant ; (vii) une soupape ; (viii) un élément d'extraction en phase solide (SPE) ; et (ix) un aspirateur en communication fluidique avec l'entrée d'échantillon du SPM pour le prélèvement d'une partie aliquote dudit fluide biologique lorsqu'il est contenu dans un récipient d'échantillon, ledit aspirateur étant couplé de manière fonctionnelle à un capteur pneumatique de niveau de fluide.
Also published as
Latest bibliographic data on file with the International Bureau