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1. (WO2016020785) SYNTHESIS OF BENZOTHIAZEPINES



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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/IB2015/055584 PR65722WO
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
23 July 2015 05 August 2014
Applicant
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2...
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing filed or furnished:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
SYNTHESIS OF BENZOTHIAZEPINES

5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C07D 281/10 (2006.01)i; A61K 31/554 (2006.01)i; A61P 3/10 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     C07D
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
A
WO 2011137135 A1 (GLAXOSMITHKLINE LLC) 03 November 2011 (2011-11-03)
1-10
cited in the application
page 24 line 15 - page 26 line 6, page 33 line 22 - page 34 line 12, page 59 line 16 - page 60 line 2,;page 17, line 5 - page 22, line 10; claims; example 26
(2)
A
WO 9605188 A (WELLCOME FOUNDATION LTD.) 22 February 1996 (1996-02-22)
1-10
cited in the application
page 21, paragraph 2 - page 24, paragraph 1; claims
(3)
A
D. J. COWAN ET. AL., "Enzymatic- and Iridium-Catalyzed Asymmetric Synthesis of a Benzothiazepinylphosphonate Bile Acid Transporter Inhibitor", JOURNAL OF ORGANIC CHEMISTRY,Vol. 78, 20 November 2013 (2013-11-20), page 12726-12734,
XP002743677
1-10
page 12726 - page 12730; figures 1-2
(4)
A
Y. WU ET. AL., "Discovery of a Highly Potent, Nonadsorbable Apical Sodium-Dependent Bile Acid Transporter Inhibitor (GSK2330672) for Treatment of Type 2 Diabetes.", JOURNAL OF MEDICINAL CHEMISTRY,Vol. 56, 16 May 2013 (2013-05-16), page 5094-5114,
XP002743678
1-10
cited in the application
page 5095, Scheme 1
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2011137135 A1
03 November 2011
AR 081337 A1
AU 2011245393 B2
CA 2795543 A1
CL 2012003009 A1
CN 102858159 A
CO 6612267 A2
CR 20120557 A
DO P2012000263 A
EA 201290909 A1
EP 2563122 A1
JP 5702853 B2
JP 2013525444 A
KR 20130060201 A
MA 34235 B1
NZ 602754 A
PE 03842013 A1
SG 184812 A1
US 2013029938 A1
UY 33353 A
WO 2011137135 A1
08 August 2012
23 January 2014
03 November 2011
08 March 2013
02 January 2013
01 February 2013
20 February 2013
15 September 2013
30 May 2013
06 March 2013
15 April 2015
20 June 2013
07 June 2013
02 May 2013
30 May 2014
04 April 2013
29 November 2012
31 January 2013
01 December 2011
03 November 2011
WO 9605188 A
22 February 1996
AP 720 A
AT 226946 T
AU 696073 B2
AU 4426096 A
BG 62048 B1
BG 101209 A
BR 9508586 A
CA 2197099 A1
CN 1161035 A
CZ 9700373 A3
DE 69528704 D1
DE 69528704 T2
DK 0775126 T3
EE 9700028 A
EP 0775126 A1
EP 1203769 A1
ES 2185711 T3
FI 970531 A
HK 1003936 A1
IL 114877 A
IS 4418 A
JP 2935756 B2
JP H10504035 A
KR 100354288 B1
NO 970585 A
NZ 290911 A
OA 10597 A
PL 318496 A1
PT 775126 E
RU 2156245 C2
SK 17797 A3
US 5910494 A
WO 9605188 A1
ZA 9506647 A
08 January 1999
15 November 2002
03 September 1998
07 March 1996
29 January 1999
29 August 1997
14 July 1998
22 February 1996
01 October 1997
13 August 1997
05 December 2002
12 June 2003
03 March 2003
15 August 1997
28 May 1997
08 May 2002
01 May 2003
07 February 1997
14 March 2003
14 July 1999
24 January 1997
16 August 1999
14 April 1998
06 January 2003
07 April 1997
28 July 1998
22 August 2002
23 June 1997
28 February 2003
20 September 2000
10 September 1997
08 June 1999
22 February 1996
10 February 1997
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
27 August 2015
Date of mailing of the international search report:
18 September 2015
Authorized officer:
Helps, Ian
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