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1. (WO2016020785) SYNTHESIS OF BENZOTHIAZEPINES
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CLAIMS

What is claimed is:

1 . A method for preparing the compound


comprising the step of preparing the compound


from 3-hydroxy-4-methoxythiophenol.

2. The method of Claim 1 wherein said 3-hydroxy-4-methoxythiophenol is prepared from 2-methoxyphenyl acetate.

3. The method of Claim 1 or Claim 2 wherein said 3-hydroxy-4-methoxythiophenol is converted to


4. The method of Claim 3 wherein the depicted structure is prepared as the corresponding dibenzoyl-L-tartrate salt.

5. The method of Claim 3 wherein the depicted structure is prepared as the corresponding di-p-toluoyl-L-tartrate salt.

6. The method of any of Claims 1 -5 wherein said 3-hydroxy-4-methoxythiophenol is converted to

which is then converted to


via a Ritter reaction.

7. The method of Claim 6 wherein said Ritter reaction uses CICH2CN.

8. The method of any of Claims 1 -5 wherein said 3-hydroxy-4-methoxythiophenol is converted to


9. The method of Claim 8 wherein said conversion includes reaction of said 3-hydroxy-4-methoxythiophenol with (R)-2-ammonio-2-ethylhexyl sulfate.

10. The method of any of Claims 1 -9 wherein said 3-hydroxy-4-methoxythiophenol is converted to

which is then converted to

which is then converted to
which is then converted t