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1. WO2016019899 - GENE COMPOSITION FOR DETECTING CELL PROLIFERATIVE ABNORMALITY OR GRADING DISEASE DEGREE AND USE THEREOF

Publication Number WO/2016/019899
Publication Date 11.02.2016
International Application No. PCT/CN2015/086367
International Filing Date 07.08.2015
IPC
C12N 15/11 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
C12N 15/11
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
C12Q 1/6813
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6813Hybridisation assays
C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
C12Q 2600/154
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
154Methylation markers
Applicants
  • 博诚研究中心 BIOCHAIN INSTITUTE, INC. [US]/[US]
  • 博尔诚(北京)科技有限公司 BIOCHAIN (BEIJING) SCIENCE & TECHNOLOGY, INC. [CN]/[CN]
Inventors
  • 韩晓亮 HAN, Xiaoliang
  • 陆彤 LU, Tong
  • 王建铭 WANG, James Jianming
Agents
  • 北京泛华伟业知识产权代理有限公司 PANAWELL & PARTNERS, LLC
Priority Data
201410389895208.08.2014CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) GENE COMPOSITION FOR DETECTING CELL PROLIFERATIVE ABNORMALITY OR GRADING DISEASE DEGREE AND USE THEREOF
(FR) COMPOSITION GÉNIQUE POUR LA DÉTECTION D'ANOMALIES DE LA PROLIFÉRATION CELLULAIRE OU POUR ÉTABLIR LE NIVEAU DE GRAVITÉ D'UNE MALADIE, ET SON UTILISATION
(ZH) 用于检测细胞增殖性异常或疾病程度分级的基因组合物及其用途
Abstract
(EN)
The present invention provides a composition, a kit and the use thereof, as well as the methods for detecting the cell proliferative abnormality in individuals or grading the disease degree of the individuals. The composition comprises nucleic acids for detecting the methylation level in at least one target region in a gene and the fragment thereof.
(FR)
La présente invention concerne une composition, un kit et son utilisation, ainsi que les méthodes permettant de détecter une anomalie de la prolifération cellulaire chez un individu ou d'établir le niveau de gravité d'une maladie chez un individu. La composition comprend des acides nucléiques permettant de détecter le niveau de méthylation dans au moins une région cible d'un gène et du fragment associé.
(ZH)
本发明提供了一种组合物,试剂盒及其用途和用于对个体中细胞增殖性异常进行检测或对个体的疾病程度进行分级的方法,所述组合物包括用于检测基因及其片段中至少一个靶区域内甲基化程度的核酸。
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