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1. WO2016019868 - SALT OF THIADIAZOLE DERIVATIVE DPP-IV INHIBITOR

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Publication Number WO/2016/019868
Publication Date 11.02.2016
International Application No. PCT/CN2015/086121
International Filing Date 05.08.2015
IPC
C07D 519/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
A61K 31/522 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
52Purines, e.g. adenine
522having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
A61P 3/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
C07C 59/265 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
59Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
235Saturated compounds having more than one carboxyl group
245containing hydroxy or O-metal groups
265Citric acid
C07C 51/41 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
51Preparation of carboxylic acids or their salts, halides, or anhydrides
41Preparation of salts of carboxylic acids by conversion of the acids or their salts into salts with the same carboxylic acid part
CPC
A61K 31/522
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
52Purines, e.g. adenine
522having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
C07C 51/41
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
51Preparation of carboxylic acids or their salts, halides or anhydrides
41Preparation of salts of carboxylic acids
C07C 59/265
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
59Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
235Saturated compounds containing more than one carboxyl group
245containing hydroxy or O-metal groups
265Citric acid
C07D 519/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applicants
  • 连云港润众制药有限公司 LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD. [CN]/[CN]
  • 北京赛林泰医药技术有限公司 CENTAURUS BIOPHARMA CO., LTD. [CN]/[CN]
Inventors
  • 刘飞 LIU, Fei
  • 彭岩 PENG, Yan
  • 朱波 ZHU, Bo
  • 徐宏江 XU, Hongjiang
  • 陈智林 CHEN, Zhilin
  • 田心 TIAN, Xin
  • 杨玲 YANG, Ling
  • 张喜全 ZHANG, Xiquan
Agents
  • 北京英赛嘉华知识产权代理有限责任公司 INSIGHT INTELLECTUAL PROPERTY LIMITED
Priority Data
201410381575.205.08.2014CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) SALT OF THIADIAZOLE DERIVATIVE DPP-IV INHIBITOR
(FR) SEL D'INHIBITEUR DE LA DPP-IV DÉRIVÉ DE THIADIAZOLE
(ZH) 噻二唑衍生物类DPP-Ⅳ抑制剂的盐
Abstract
(EN)
Provided are a citric acid salt of a thiadiazole derivative DPP-IV inhibitor, and preparation method, pharmaceutical composition and use thereof for treating and/or preventing diseases benefiting from DPP-IV inhibition, particularly for treating and/or preventing type II diabetes.
(FR)
L'invention concerne un sel d'acide citrique d'un inhibiteur de la DPP-IV dérivé de thiadiazole. Elle concerne une méthode de préparation, une composition pharmaceutique et l'utilisation de celui-ci pour le traitement et/ou la prévention de maladies contre lesquelles l'inhibition de la DPP-IV est bénéfique, en particulier pour le traitement et/ou la prévention du diabète de type II.
(ZH)
本发明提供了噻二唑衍生物类DPP-Ⅳ抑制剂的枸橼酸盐，其制备方法、其药物组合物及其治疗和/或预防受益于DPP-Ⅳ抑制的疾病、尤其是治疗和/或预防Ⅱ型糖尿病的用途。
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