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1. (WO2016019868) SALT OF THIADIAZOLE DERIVATIVE DPP-IV INHIBITOR
Latest bibliographic data on file with the International Bureau
Pub. No.: WO/2016/019868 International Application No.: PCT/CN2015/086121
Publication Date: 11.02.2016 International Filing Date: 05.08.2015
IPC:
C07D 519/00 (2006.01) ,A61K 31/522 (2006.01) ,A61P 3/10 (2006.01) ,C07C 59/265 (2006.01) ,C07C 51/41 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
519
Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
52
Purines, e.g. adenine
522
having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
08
for glucose homeostasis
10
for hyperglycaemia, e.g. antidiabetics
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
59
Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
235
Saturated compounds having more than one carboxyl group
245
containing hydroxy or O-metal groups
265
Citric acid
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
51
Preparation of carboxylic acids or their salts, halides, or anhydrides
41
Preparation of salts of carboxylic acids by conversion of the acids or their salts into salts with the same carboxylic acid part
Applicants:
连云港润众制药有限公司 LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD. [CN/CN]; 中国江苏省连云港市 连云港经济技术开发区大浦工业区金桥路16号 No. 16 Jinqiao Road, Dapu Industry Park, Lianyungang Economy and Technology Development Zone Lianyungang City, Jiangsu 222069, CN
北京赛林泰医药技术有限公司 CENTAURUS BIOPHARMA CO., LTD. [CN/CN]; 中国北京市 海淀区闵庄路3号16号楼 No. 16 Building, No. 3 Minzhuang Road, Haidian District Beijing 100195, CN
Inventors:
刘飞 LIU, Fei; CN
彭岩 PENG, Yan; CN
朱波 ZHU, Bo; CN
徐宏江 XU, Hongjiang; CN
陈智林 CHEN, Zhilin; CN
田心 TIAN, Xin; CN
杨玲 YANG, Ling; CN
张喜全 ZHANG, Xiquan; CN
Agent:
北京英赛嘉华知识产权代理有限责任公司 INSIGHT INTELLECTUAL PROPERTY LIMITED; 中国北京市 海淀区知春路甲48号盈都大厦A座19A Suite 19A, Tower A, InDo Building, No. 48A Zhichun Road, Haidian District Beijing 100098, CN
Priority Data:
201410381575.205.08.2014CN
Title (EN) SALT OF THIADIAZOLE DERIVATIVE DPP-IV INHIBITOR
(FR) SEL D'INHIBITEUR DE LA DPP-IV DÉRIVÉ DE THIADIAZOLE
(ZH) 噻二唑衍生物类DPP-Ⅳ抑制剂的盐
Abstract:
(EN) Provided are a citric acid salt of a thiadiazole derivative DPP-IV inhibitor, and preparation method, pharmaceutical composition and use thereof for treating and/or preventing diseases benefiting from DPP-IV inhibition, particularly for treating and/or preventing type II diabetes.
(FR) L'invention concerne un sel d'acide citrique d'un inhibiteur de la DPP-IV dérivé de thiadiazole. Elle concerne une méthode de préparation, une composition pharmaceutique et l'utilisation de celui-ci pour le traitement et/ou la prévention de maladies contre lesquelles l'inhibition de la DPP-IV est bénéfique, en particulier pour le traitement et/ou la prévention du diabète de type II.
(ZH) 本发明提供了噻二唑衍生物类DPP-Ⅳ抑制剂的枸橼酸盐，其制备方法、其药物组合物及其治疗和/或预防受益于DPP-Ⅳ抑制的疾病、尤其是治疗和/或预防Ⅱ型糖尿病的用途。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)