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1. WO2016018701 - FACTOR XIa INHIBITORS

Publication Number WO/2016/018701
Publication Date 04.02.2016
International Application No. PCT/US2015/041646
International Filing Date 23.07.2015
IPC
C07D 401/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
A61K 31/4184 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41641,3-Diazoles
4184condensed with carbocyclic rings, e.g. benzimidazoles
A61P 7/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
CPC
A61P 7/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
C07D 401/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
Applicants
  • MERCK SHARP & DOHME CORP. [US]/[US]
  • LIU, Weiguo [US]/[US] (US)
  • EDMONDSON, Scott, D. [US]/[US] (US)
  • GUO, Zhuyan [US]/[US] (US)
  • HRUZA, Alan [US]/[US] (US)
  • SO, Sung-Sau [US]/[US] (US)
  • SUN, Wanying [US]/[US] (US)
  • ALI, Amjad [US]/[US] (US)
  • KUANG, Rongze [US]/[US] (US)
  • GAO, Ying-Duo [US]/[US] (US)
  • OGAWA, Anthony, K. [US]/[US] (US)
Inventors
  • LIU, Weiguo
  • EDMONDSON, Scott, D.
  • GUO, Zhuyan
  • HRUZA, Alan
  • SO, Sung-Sau
  • SUN, Wanying
  • ALI, Amjad
  • KUANG, Rongze
  • GAO, Ying-Duo
  • OGAWA, Anthony, K.
Common Representative
  • MERCK SHARP & DOHME CORP.
Priority Data
62/029,77228.07.2014US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) FACTOR XIa INHIBITORS
(FR) INHIBITEURS DU FACTEUR XIA
Abstract
(EN)
The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
(FR)
La présente invention concerne un composé de formule (I) et des compositions pharmaceutiques comprenant un ou plusieurs desdits composés, ainsi que des méthodes d'utilisation desdits composés pour traiter ou prévenir les thromboses, les embolies, l'hypercoagulabilité ou les modifications fibrotiques. Ces composés sont des inhibiteurs sélectifs du facteur XIa ou des inhibiteurs doubles du facteur XIa et de la kallicréine plasmatique.
Also published as
Latest bibliographic data on file with the International Bureau