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1. (WO2016016865) A PROCESS FOR THE PREPARATION OF NUCLEOSIDE PHOSPHORAMIDATE
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CLAIMS

1. A compound of Formula 2


Formula 2

wherein X' is selected from the group consisting

a)


wherein R is substituted or un-substituted n-alkyl, branched alkyl,cycloalkyl; halogen; nitro; or aryl, wherein said aryl is optionally substituted with at least one of Ci-C6 alkyl, C2-C6alkenyl, C2-C6alkynyl, Ci-C6alkoxy, F, CI, Br, I, nitro, cyano, Ci-C6haloalkyl,— N(R1 )2, Ci-C6acylamino, -NHS02Ci-C6 alkyl, -S02N(R1')2, COR1", and -S02Ci-C6 alkyl; wherein R1 is independently hydrogen or Ci-Cioalkyl; and R1" is -OR1' or -N(Rr)2;

b)

wherein R is substituted or un-substituted n-alkyl, branched alkyl,cycloalkyl; halogen; nitro or aryl, wherein said aryl is optionally substituted with at least one of Ci-C6 alkyl, C2-C6alkenyl, C2-C6alkynyl, Ci-C6alkoxy, F, CI, Br, I, nitro, cyano, Ci-C6haloalkyl,— N(RX )2, Ci-Ceacylamino, -NHS02Ci-C6 alkyl, -S02N(Rr)2, COR1", and -S02Ci-C6 alkyl; wherein R is independently hydrogen or Ci-C20alkyl; and R is -OR or ~N(R )2;


wherein R is H, N02, CI, CHF2 or CF3;

d)


wherein R is H, N02, CI, or CF3;

and

e)


wherein R is hydrogen, substituted or un-substituted alkyl, or alkylaryl.

2. The compound according to claim 1 , wherein said aryl is an optionally substituted phenyl or naphthyl.

3. A process for preparing the compound of Formula 2 as claimed in claim 1 comprising reactinga phosphorochloridate of following Formula


with

a)


Wherein R is as defined in claim 1 ;

b)

wherein R is as defined in claim 1 ; c)


wherein R is as defined in claim 1 ;

d)


wherein R is as defined in claim 1 ; or

e)


wherein R is as defined in claim 1.

4. The process of claim 3 wherein the phosphorochloridate of the Formula


is reacted with 1-hydroxybenzotriazole or 5-(Difluoromethoxy)-lH-benzimidazole-2-thiol, 2-Mercapto-5-methoxybenzimidazole;cyanuric acid; 2-oxazolidinone; 2-Hydroxy Pyridine; or a derivative thereof .

5. The process of claim 4 wherein the phosphorochloridate of the Formula


is reacted with S-4-phenyloxazolidine; 2-hydroxy-3-nitro-5-(trifluoromethyl)pyridine;2-Hydroxy-5-fluoropyridine; 2-Hydroxy-5-nitropyridine; or 2-Hydroxy-3, 5-dinitropyridine.

6. A process for the preparation of Sofosbuvir comprising reacting a compound of Formula 2


Formula 2

with a compound of Formula 3

Formula 3

7. Use of compound of Formula 2 for the preparation of Sofosbuvir.