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1. WO2016005985 - METHOD FOR REPROGRAMMING CELLS

Publication Number WO/2016/005985
Publication Date 14.01.2016
International Application No. PCT/IL2015/050715
International Filing Date 09.07.2015
IPC
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
073
Embryonic cells or tissues; Foetal cells or tissues
C12N 5/073 (2010.01)
CPC
C12N 2501/119
C12N 2501/60
C12N 2501/606
C12N 2501/91
C12N 2506/13
C12N 5/0605
Applicants
  • YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. [IL/IL]; Hi Tech Park, The Edmond J. Safra Campus The Hebrew University of Jerusalem Ltd. Givat Ram P.O. Box 39135 9139002 Jerusalem, IL
Inventors
  • BUGANIM, Yossi; IL
Agents
  • EHRLICH, Gal; G.E. Ehrlich (1995) Ltd. 11 Menachem Begin Road 5268104 Ramat Gan, IL
Priority Data
62/022,29609.07.2014US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR REPROGRAMMING CELLS
(FR) MÉTHODE POUR REPROGRAMMER DES CELLULES
Abstract
(EN)
A method of generating an induced trophoblast stem cell (iTSC) from a cell is provided. Accordingly there is provided a method comprising expressing within the cell at least one exogenous transcription factor selected from the group consisting of Gata3, Eomes and Tfap2c, under conditions which allow generation of an iTSC from the cell, thereby generating the iTSC from the cell, with the proviso that the method does not consist of expressing within the cell Eomes, Cdx2, Elf5, cMyc and Klf4. Also provided are nucleic acid constructs, isolated cells and iTSCs.
(FR)
La présente invention concerne une méthode de génération d'une cellule souche trophoblastique induite (iTSC) à partir d'une cellule. Par conséquent, l'invention concerne une méthode consistant à exprimer, à l'intérieur de ladite cellule, au moins un facteur de transcription exogène choisi dans le groupe constitué par Gata3, Eomes et Tfap2c, dans des conditions qui permettent la génération d'une iTSC à partir de ladite cellule, ce qui permet de générer l'iTSC à partir de ladite cellule, à condition que la méthode ne consiste pas à exprimer, à l'intérieur de ladite cellule, Eomes, Cdx2, Elf5, cMyc et Klf4. L'invention concerne également des constructions d'acides nucléiques, des cellules isolées et des iTSC.
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