WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2016005874) PROCESS FOR THE PREPARATION OF REGORAFENIB AND ITS CRYSTALLINE FORMS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/005874    International Application No.:    PCT/IB2015/055083
Publication Date: 14.01.2016 International Filing Date: 06.07.2015
IPC:
C07D 213/81 (2006.01)
Applicants: SHILPA MEDICARE LIMITED [IN/IN]; #12-6-214/A1,Hyderabad Road Raichur-584 135, Karnataka (IN)
Inventors: RAMPALLI, Sriram; (IN).
UPALLA, Lav Kumar; (IN).
RAMACHANDRULA, Krishna Kumar; (IN).
PUROHIT, Prashant; (IN).
AKSHAY KANT, Chaturvedi; (IN)
Priority Data:
3391/CHE/2014 09.07.2014 IN
3396/CHE/2014 09.07.2014 IN
Title (EN) PROCESS FOR THE PREPARATION OF REGORAFENIB AND ITS CRYSTALLINE FORMS
(FR) PROCÉDÉ POUR LA PRÉPARATION DU RÉGORAFÉNIB ET SES FORMES CRISTALLINES
Abstract: front page image
(EN)The present invention relates to a process for the preparation of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide or Regorafenib (I): Formula (I). The present invention further relates to a process for the purification of 4-[4-({[4-chloro-3-(trifluoromethyl) phenyl] carbamoyl} amino)-3-fluorophenoxy]-N-methylpyridine-2- carboxamide or Regorafenib (I) to provide highly pure material. The present invention further relates to a process for the preparation stable crystalline material of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]- N-methyl pyridine-2-carboxamide or Regorafenib (I) useful in the preparation of pharmaceutical compositions for the treatment of cancer.
(FR)La présente invention concerne un procédé pour la préparation de 4-[4-({[4-chloro-3- (trifluorométhyle)phényl]carbamoyl}amino)-3-fluorophénoxy]-N-méthylpyridine -2-carboxamide ou du régorafénib (I) : Formule (I). La présente invention concerne en outre un procédé pour la purification de 4-[4-({ [4-chloro-3-(trifluorométhyle)phényl]carbamoyl}amino)-3-fluorophénoxy]-N-méthylpyridine-2-carboxamide ou du régorafénib (I) pour fournir un matériau hautement pur. La présente invention concerne en outre un procédé pour la préparation d'un matériau cristallin stable de 4-[4-({[4-chloro-3-(trifluorométhyl)phényl]carbamoyl}amino) -3-fluorophénoxy]-N-méthylpyridine-2-carboxamide ou de régorafénib (I) utiles dans la préparation de compositions pharmaceutiques pour le traitement du cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)