Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2016003919) ANALOGS OF PRIDOPIDINE, THEIR PREPARATION AND USE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2016/003919 International Application No.: PCT/US2015/038349
Publication Date: 07.01.2016 International Filing Date: 29.06.2015
IPC:
A61K 31/451 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
445
Non-condensed piperidines, e.g. piperocaine
451
having a carbocyclic ring directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
Applicants:
TEVA PHARMACEUTICAL INDUSTRIES LTD. [IL/IL]; 5 Basel Street P.O. Box 3190 49131 Petach Tikva, IL (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
TEVA PHARMACEUTICALS USA, INC. [US/US]; 1090 Horsham Road North Wales, PA 19454, US (BB)
SCHMIDT, Malle [EE/EE]; EE (US)
PÄRI, Malle [EE/EE]; EE (US)
LAOS, Marit [EE/EE]; EE (US)
MAASALU, Ants [EE/EE]; EE (US)
KALJUSTE, Kalle [EE/EE]; EE (US)
Inventors:
SCHMIDT, Malle; EE
PÄRI, Malle; EE
LAOS, Marit; EE
MAASALU, Ants; EE
KALJUSTE, Kalle; EE
Agent:
WHITE, John, P.; US
Priority Data:
62/019,33730.06.2014US
62/076,43606.11.2014US
Title (EN) ANALOGS OF PRIDOPIDINE, THEIR PREPARATION AND USE
(FR) ANALOGUES DE PRIDOPIDINE, LEUR PRÉPARATION ET UTILISATION
Abstract:
(EN) This invention provides an isolated compound having the structure: The invention also provides for a process for preparing 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-4-ol, 1-(3,3-bis(3-(methylsulfonyl)phenyl)propyl)-4-(3-(methylsulfonyl) phenyl)piperidone, 1,4-bis((3-(1 -propylpiperidin-4-yl)phenyl)sulfonyl)butane, (3R,4S)-4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-3-ol, 4-(3-(methylsulfonyl)phenyl)-l-propylpiperidine 1- oxide, 1-(2-methylpentyl)-4-(3-(methylsulfonyl)phenyl)piperidine, 4-(3-(methylsulfinyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridine, and 4-(3-(methylsulfonyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridine. This invention also provides an impurity or a salt thereof for use, as a reference standard to detect trace amounts of the impurity in a pharmaceutical composition comprising pridopidine or a pharmaceutically acceptable salt thereof. This invention further provides a process for producing a pridopidine drug product comprising obtaining a pridopidine drug substance and mixing the pridopidine drug substance with suitable excipients so as to produce the pridopidine drug product. This invention also provides a process for producing a pridopidine drug product. This invention also provides a process of distributing a pridopidine drug product.
(FR) L'invention concerne un composé isolé ayant la structure: . L'invention concerne également un procédé de préparation de 4-(3-(méthylsulfonyl)phényl)-1-propylpipéridin-4-ol, de 1-(3,3-bis(3-(méthylsulfonyl)phényl)propyl)-4-(3-(méthylsulfonyl)phényl)pipéridone, de 1,4-bis((3-(1-propylpipéridin-4-yl)phényl)sulfonyl)butane, de (3R,4S)-4-(3-(méthylsulfonyl)phényl)-1-propylpipéridin-3-ol, de 4-(3-(méthylsulfonyl)phényl)-l-propylpipéridine 1-oxyde, de 1-(2-méthylpentyl)-4-(3-(méthylsulfonyl)phényl)pipéridine, de 4-(3-(méthylsulfinyl)phényl)-1-propyl-1,2,3,6-tétrahydropyridine et de 4-(3-(méthylsulfonyl)phényl)-1-propyl-1,2,3,6-tétrahydropyridine. L'invention concerne également une impureté ou un sel de celle-ci pour une utilisation comme standard de référence pour détecter des quantités à l'état de traces de l'impureté dans une composition pharmaceutique comprenant de la pridopidine ou un sel pharmaceutiquement acceptable de celle-ci. L'invention concerne également un procédé de production d'un produit médicamenteux de pridopidine comprenant l'obtention d'une substance médicamenteuse de pridopidine et le mélange de la substance médicamenteuse de pridopidine avec des excipients appropriés de manière à produire le produit médicamenteux de pridopidine. L'invention concerne également un procédé de production d'un produit médicamenteux de pridopidine. L'invention concerne également un procédé de distribution d'un produit médicamenteux de pridopidine.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA2951494CN106456618AU2015284385IL249601JP2017519839EA201790101
EP3160470IN201717000477BR112016030968