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1. WO2016003320 - METHOD FOR TREATING PATIENTS HAVING CANCEROUS SKIN DISEASES (VARIANTS)

Publication Number WO/2016/003320
Publication Date 07.01.2016
International Application No. PCT/RU2015/000382
International Filing Date 22.06.2015
Chapter 2 Demand Filed 03.12.2015
IPC
A61K 35/30 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
30Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
A61K 35/36 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
A61K 38/17 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 17/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
CPC
A61K 35/30
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
30Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
A61K 35/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
A61K 38/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
Applicants
  • ДИАМОНДЗЛИТЕ ЛИМИТЕД DIAMONDZLITE LIMITED
  • НАЗАРЕНКО, Анна Борисовна NAZARENKO, Anna Borisovna [RU]/[RU]
Inventors
  • НАЗАРЕНКО, Анна Борисовна NAZARENKO, Anna Borisovna
  • СОКОЛОВ, Михаил Анатольевич SOKOLOV, Mikhail Anatolevich
Agents
  • КОПЫРИН, Юрий Иосифович KOPYRIN, Yury Iosifovich
Priority Data
201412651001.07.2014RU
Publication Language Russian (RU)
Filing Language Russian (RU)
Designated States
Title
(EN) METHOD FOR TREATING PATIENTS HAVING CANCEROUS SKIN DISEASES (VARIANTS)
(FR) PROCÉDÉ DE TRAITEMENT DE PATIENTS SOUFFRANT D'AFFECTIONS ONCOLOGIQUES DE LA PEAU
(RU) СПОСОБ ЛЕЧЕНИЯ ПАЦИЕНТОВ С ОНКОЛОГИЧЕСКИМИ ЗАБОЛЕВАНИЯМИ КОЖИ (ВАРИАНТЫ)
Abstract
(EN)
The invention relates to the field of medicine. Treating patients having cancerous skin diseases involves determining the size of a tumor and carrying out intradermal injections around the center of the damaged tissue prior to and/or following tumor removal, or directly into the tumor tissue, using a solution of a protein-polypeptide complex in a pharmaceutically acceptable carrier containing 0.05-0.4 mg of the complex. The protein-polypeptide complex is produced from a homogenate of embryonic nerve and skin tissues of hoofed farm animals. The protein-polypeptide complex contains proteins and polypeptides having a molecular weight of between 5 and 200 kDa, with a fraction having an average molecular weight of between 10 and 120 kDa constituting at least 80%; the total protein concentration is between 0.2 and 4.2 mg/ml, with maximum absorption of the UV spectrum of the solution happening at wavelengths of 280+5 nm, with a peak existing at a wavelength of 274-284 nm in the UV visible portion of the spectrum, with specific bands existing in a pi value interval from 4.2 to 8.4 during isoelectric focusing in a 5% polyacrylamide gel. A skin cancer treatment method involves using the protein-polypeptide complex externally in the form of applications, and as a course of preventive skin cancer treatment, using the protein-polypeptide complex in the form of creams, gels, and photoprotective compositions.
(FR)
L'invention se rapporte au domaine de la médecine. Le traitement de patients souffrant d'affections oncologiques de la peau consiste à déterminer la taille de la tumeur, et effectuer une injection intradermique, autour du foyer des tissus atteints avant et/ou après avoir éliminé la tumeur, ou immédiatement dans les tissus de la tumeur, d'une solution d'un complexe de protéines-polypeptides dans un excipient pharmaceutiquement acceptable, avec une concentration du complexe allant de 0,05 à 0,4 mg. Le complexe de protéines-polypeptides est obtenu à partir d'un homogénat de tissus nerveux et cutanés embryonnaires d'animaux de ferme ongulés. Le complexe de protéines-polypeptides comprend des protéines et des polypeptides d'une masse moléculaire de 5 à 200 kDa, avec une concentration de la fraction ayant une masse moléculaire moyenne dans une plage de 10 à 200 kDa d'au moins 80 % et une concentration totale en protéines de 0,2-4,2 mg/ml, et maximum d'absorption en spectre ultraviolet de la solution à une longueur d'onde de 280+5 nm, la présence d'un pic à une longueur d'onde de 274-284 nm dans le domaine spectral UV-visible, une présence de bandes spécifiques dans une plage de valeurs pi de 4,2 à 8,4 avec iso-électro-focalisation dans un gel de polyacrylamide à 5%. Ce procédé de traitement du cancer de la peau consiste à utiliser le complexe de protéines-polypeptides en externe sous forme d'applications, et le traitement prophylactique régulier du cancer de la peau utilise le complexe de protéines-polypeptides sous forme de crèmes, de gels et de compositions de protection contre la lumière.
(RU)
Изобретения относятся к медицине. Лечение пациентов с онкологическими заболеваниями кожи включает определение размера опухоли и проведение внутрикожных инъекций вокруг очага пораженной ткани до и/или после удаления опухоли, или непосредственно в ткань опухоли, раствором белково- полипептидного комплекса (БПК) в фармацевтически приемлемом носителе с содержанием комплекса 0,05-0,4 мг. БПК получают из гомогената эмбриональной нервной и кожной тканей копытных сельскохозяйственных животных. БПК содержит белки и полипетиды с молекулярной массой от 5 до 200 кДа, и с содержанием фракции со средней молекулярной массой в пределах от 10 до 120 кДа не менее 80%, общей концентрацией белка 0,2-4,2 мг/мл, с максимумом поглощения ультрафиолетового спектра раствора при длине волны 280+5 нм, наличием пика при длине волны 274-284 нм в УФ-видимой области спектра, наличием специфических полос в интервале значений pi от 4,2 до 8,4 при изоэлектрофокусировке в 5%-ном полиакриламидном геле. Способ лечения рака кожи предусматривает использование БПК наружно в виде аппликаций, и курсовое профилактическое лечение рака кожи, используя БПК в виде кремов, гелей, фотозащитных композиций.
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