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1. (WO2015198334) IDENTIFICATION OF CANCER STEM CELL MARKERS AND USE OF SAME FOR DIAGNOSIS AND TREATMENT
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2015/198334 International Application No.: PCT/IL2015/050663
Publication Date: 30.12.2015 International Filing Date: 25.06.2015
IPC:
G01N 33/50 (2006.01) ,C12Q 1/68 (2006.01) ,G01N 33/574 (2006.01) ,A61P 35/00 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. [IL/IL]; The Chaim Sheba Medical Center Tel HaShomer 5262000 Ramat-Gan, IL
Inventors:
DEKEL, Benjamin; IL
HARARI-STEINBERG, Orit; IL
Agent:
EHRLICH, Gal; G. E. Ehrlich (1995) Ltd. 11 Menachem Begin Road 5268104 Ramat Gan, IL
Priority Data:
62/016,77325.06.2014US
Title (EN) IDENTIFICATION OF CANCER STEM CELL MARKERS AND USE OF SAME FOR DIAGNOSIS AND TREATMENT
(FR) IDENTIFICATION DE CELLULES SOUCHES CANCÉREUSES ET UTILISATION DE CELLES-CI POUR DES DIAGNOSTICS ET TRAITEMENTS
Abstract:
(EN) A method of identifying cancer stem cell markers in a human primary tumor is disclosed. The method comprises: (a) in vivo passaging the primary tumor; and (b) comparing a level of at least one antigen in a first population of passaged tumor cells of the primary tumor with a second population of tumor cells of the primary tumor, wherein an increase in the amount of the antigen in the first population of tumor cells as compared to the amount of the antigen in the second population of tumor cells is indicative of a cancer stem cell marker in the human primary tumor.
(FR) L'invention concerne un procédé d'identification de marqueurs de cellules souches cancéreuses dans une tumeur primaire humaine. Le procédé comprend : (a) le passage in vivo de la tumeur primaire; et (b) la comparaison d'un niveau d'au moins un antigène dans une première population de cellules tumorales ayant subi plusieurs passages de la tumeur primaire avec une seconde population de cellules tumorales de la tumeur primaire, une augmentation de la quantité de l'antigène dans la première population de cellules tumorales par rapport à la quantité de l'antigène dans la deuxième population de cellules tumorales étant indicatif d'un marqueur de cellules souches cancéreuses dans la tumeur primaire humaine.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
SG11201610630RAU2015278659CN106537148KR1020170041192IL249741CA2953663
US20170199195EP3161480IN201727001584JP2017528114