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1. (WO2015192817) PYRAZOLOTRIAZINES AS INHIBITORS OF NUCLEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2015/192817 International Application No.: PCT/CZ2015/000063
Publication Date: 23.12.2015 International Filing Date: 17.06.2015
IPC:
C07D 487/04 (2006.01) ,A61K 31/53 (2006.01) ,A61P 35/00 (2006.01) ,A61P 35/02 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
53
having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
02
specific for leukemia
Applicants:
MASARYKOVA UNIVERZITA [CZ/CZ]; Zerotinovo namesti 9 60177 Brno, CZ
Inventors:
DAMBORSKY, Jiri; CZ
NIKULENKOV, Fedor; RU
SISAKOVA, Alexandra; SK
HAVEL, Stepan; CZ
KREJCI, Lumir; CZ
CARBAIN, Benoit; FR
BREZOVSKY, Jan; CZ
DANIEL, Lukas; CZ
PARUCH, Kamil; CZ
Agent:
HARTVICHOVA, Katerina; CZ
Priority Data:
14173242.020.06.2014EP
Title (EN) PYRAZOLOTRIAZINES AS INHIBITORS OF NUCLEASES
(FR) PYRAZOLOTRIAZINES EN TANT QU'INHIBITEURS DE NUCLÉASES
Abstract:
(EN) The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3 and R4 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases. ˙
(FR) L'invention concerne des composés représentés par la formule structurelle (1) : dans laquelle R1, R2, R3 et R4 sont tels que définis dans les revendications. Les composés sont des inhibiteurs de nucléases, et sont utiles en particulier dans un procédé de traitement et/ou de prévention de maladies prolifératives, de maladies neurodégénératives, et d'autres maladies associées à l'instabilité génomique.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)