WO2015191907 BETA-LACTAMASE INHIBITORS

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Publication Number WO/2015/191907

Publication Date 17.12.2015

International Application No. PCT/US2015/035407

International Filing Date 11.06.2015

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Applicants

VENATORX PHARMACEUTICALS, INC. [US]/[US]

Inventors

BURNS, Christopher, J.
DAIGLE, Denis
LIU, Bin
JACKSON, Randy, W.
HAMRICK, Jodie
MCGARRY, Daniel
PEVEAR, Daniel, C.
TROUT, Robert, E. Lee

Agents

HARDT, Ingo, H.

Priority Data

62/010,940	11.06.2014	US
62/010,968	11.06.2014	US
62/010,969	11.06.2014	US
62/118,227	19.02.2015	US

Publication Language English (en)

Filing Language English (EN)

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Title

(EN) BETA-LACTAMASE INHIBITORS

(FR) INHIBITEURS DE BÊTA-LACTAMASES

Abstract

(EN) Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

(FR) La présente invention concerne des composés et des compositions qui modulent l'activité des bêta-lactamases. Dans certains modes de réalisation, les composés décrits inhibent les bêta-lactamases. Dans d'autres modes de réalisation, les composés décrits sont utiles dans le traitement d'infections bactériennes.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
F	ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
5	Compounds containing elements of Groups 3 or 13 of the Periodic System
02	Boron compounds

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
69	Boron compounds

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41	having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425	Thiazoles
429	condensed with heterocyclic ring systems
43	Compounds containing 4-thia-1-azabicyclo heptane ring systems, i.e. compounds containing a ring system of the formula , e.g. penicillins, penems

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31	Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
F	ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
5	Compounds containing elements of Groups 3 or 13 of the Periodic System
02	Boron compounds

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1. WO2015191907 - BETA-LACTAMASE INHIBITORS

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
F	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
5	Compounds containing elements of Groups 3 or 13 of the Periodic System
02	Boron compounds
025	Boronic and borinic acid compounds

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
185	Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19	Carboxylic acids, e.g. valproic acid
195	having an amino group
197	the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198	Alpha-aminoacids, e.g. alanine, edetic acids [EDTA],

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
185	Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19	Carboxylic acids, e.g. valproic acid
195	having an amino group
197	the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198	Alpha-aminoacids, e.g. alanine, edetic acids [EDTA],