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1. (WO2015188782) METHOD FOR PREPARING SOFOSBUVIR
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2015/188782 International Application No.: PCT/CN2015/081368
Publication Date: 17.12.2015 International Filing Date: 12.06.2015
IPC:
C07H 19/10 (2006.01) ,C07H 1/02 (2006.01) ,C07F 9/24 (2006.01) ,C07F 9/28 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
06
Pyrimidine radicals
10
with the saccharide radical being esterified by phosphoric or polyphosphoric acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1
Processes for the preparation of sugar derivatives
02
Phosphorylation
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
06
without P-C bonds
22
Amides of acids of phosphorus
24
Esteramides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
28
with one or more P-C bonds
Applicants:
正大天晴药业集团股份有限公司 CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD [CN/CN]; 中国江苏省连云港市 海州区郁州南路369号 No. 369, Yuzhou South Rd., Haizhou District Lianyungang, Jiangsu 222062, CN
Inventors:
张寅生 ZHANG, Yinsheng; CN
敖汪伟 AO, Wangwei; CN
王庆璘 WANG, Qinglin; CN
林志强 LIN, Zhiqiang; CN
Agent:
北京英赛嘉华知识产权代理有限责任公司 INSIGHT INTELLECTUAL PROPERTY LIMITED; 中国北京市 海淀区知春路甲48号盈都大厦A座19A Suite 19A, Tower A, InDo Building, No. 48A Zhichun Road, Haidian District Beijing 100098, CN
Priority Data:
201410260643.X12.06.2014CN
Title (EN) METHOD FOR PREPARING SOFOSBUVIR
(FR) PROCÉDÉ POUR LA PRÉPARATION DE SOFOSBUVIR
(ZH) 索非布韦的制备方法
Abstract:
(EN) The present invention relates to a method for preparing sofosbuvir. In particular, provided in the present invention is a more stereoselective preparation method. The preparation method has the advantages of a richer required isomer prepared and obtained without separating the intermediate, thereby greatly reducing the production cost, and being suitable for industrialized production.
(FR) La présente invention concerne un procédé pour la préparation de sofosbuvir. En particulier, la présente invention concerne un procédé de préparation plus stéréosélectif. Le procédé de préparation présente les avantages d'un plus riche isomère voulu préparé et obtenu sans séparation de l'intermédiaire, ce qui permet de réduire fortement le coût de production, et d'être approprié pour une production industrialisée.
(ZH) 本发明涉及索非布韦的制备方法,具体而言,本发明提供了一种更具立体选择性的制备方法,在不分离中间体的前提下,制备得到的所需异构体更为富集,从而大大降低生产成本,适合于工业化生产。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)