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1. WO2015188782 - METHOD FOR PREPARING SOFOSBUVIR

Publication Number WO/2015/188782
Publication Date 17.12.2015
International Application No. PCT/CN2015/081368
International Filing Date 12.06.2015
IPC
C07H 19/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
06Pyrimidine radicals
10with the saccharide radical being esterified by phosphoric or polyphosphoric acids
C07H 1/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
02Phosphorylation
C07F 9/24 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
06without P-C bonds
22Amides of acids of phosphorus
24Esteramides
C07F 9/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
28with one or more P-C bonds
CPC
C07H 1/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
02Phosphorylation
C07H 19/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides ; Anhydro-derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
06Pyrimidine radicals
10with the saccharide radical esterified by phosphoric or polyphosphoric acids
Applicants
  • 正大天晴药业集团股份有限公司 CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD [CN]/[CN]
Inventors
  • 张寅生 ZHANG, Yinsheng
  • 敖汪伟 AO, Wangwei
  • 王庆璘 WANG, Qinglin
  • 林志强 LIN, Zhiqiang
Agents
  • 北京英赛嘉华知识产权代理有限责任公司 INSIGHT INTELLECTUAL PROPERTY LIMITED
Priority Data
201410260643.X12.06.2014CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) METHOD FOR PREPARING SOFOSBUVIR
(FR) PROCÉDÉ POUR LA PRÉPARATION DE SOFOSBUVIR
(ZH) 索非布韦的制备方法
Abstract
(EN)
The present invention relates to a method for preparing sofosbuvir. In particular, provided in the present invention is a more stereoselective preparation method. The preparation method has the advantages of a richer required isomer prepared and obtained without separating the intermediate, thereby greatly reducing the production cost, and being suitable for industrialized production.
(FR)
La présente invention concerne un procédé pour la préparation de sofosbuvir. En particulier, la présente invention concerne un procédé de préparation plus stéréosélectif. Le procédé de préparation présente les avantages d'un plus riche isomère voulu préparé et obtenu sans séparation de l'intermédiaire, ce qui permet de réduire fortement le coût de production, et d'être approprié pour une production industrialisée.
(ZH)
本发明涉及索非布韦的制备方法,具体而言,本发明提供了一种更具立体选择性的制备方法,在不分离中间体的前提下,制备得到的所需异构体更为富集,从而大大降低生产成本,适合于工业化生产。
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