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1. WO2015185650 - CARBAMATE DERIVATIVES WHICH ARE BOTH PHOSPHODIESTERASE 4 (PDE4) ENZYME INHIBITORS AND MUSCARINIC M3 RECEPTOR ANTAGONISTS

Publication Number WO/2015/185650
Publication Date 10.12.2015
International Application No. PCT/EP2015/062419
International Filing Date 03.06.2015
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
453
Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
02
containing not further condensed quinuclidine ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
439
the ring forming part of a bridged ring system, e.g. quinuclidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
C07D 453/02 (2006.01)
A61K 31/439 (2006.01)
A61P 11/00 (2006.01)
CPC
A61K 31/444
A61K 9/0073
C07D 453/02
Applicants
  • CHIESI FARMACEUTICI S.P.A. [IT/IT]; Via Palermo, 26/A I-43100 Parma, IT
Inventors
  • ARMANI, Elisabetta; IT
  • AMARI, Gabriele; IT
  • CAPALDI, Carmelida; IT
  • BAKER-GLENN, Charles; IT
Agents
  • MINOJA, Fabrizio; IT
Priority Data
14171263.805.06.2014EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CARBAMATE DERIVATIVES WHICH ARE BOTH PHOSPHODIESTERASE 4 (PDE4) ENZYME INHIBITORS AND MUSCARINIC M3 RECEPTOR ANTAGONISTS
(FR) DÉRIVÉS DE CARBAMATE QUI SONT À LA FOIS DES INHIBITEURS DE L'ENZYME PHOSPHODIESTÉRASE 4 (PDE4) ET DES ANTAGONISTES DES RÉCEPTEURS MUSCARINIQUES M3
Abstract
(EN)
The invention relates to novel compounds which are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof. (formula I)
(FR)
L'invention concerne de nouveaux composés qui sont à la fois des inhibiteurs de l'enzyme phosphodiestérase 4 (PDE4) et des antagonistes des récepteurs muscariniques M3, des procédés de préparation de tels composés, des compositions les contenant et leur utilisation thérapeutique. (formule I)
Latest bibliographic data on file with the International Bureau