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1. WO2015185130 - 3,5-DICHLORO,4-(3,4-(CYCLO-)ALKOXYPHENYL)--2-CARBONYLOXY)ETHYL)PYRIDINE DERIVATIVES AS PDE-4 INHIBITORS

Publication Number WO/2015/185130
Publication Date 10.12.2015
International Application No. PCT/EP2014/061604
International Filing Date 04.06.2014
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
453
Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
06
Antiasthmatics
C07D 453/00 (2006.01)
A61K 31/4427 (2006.01)
A61P 11/06 (2006.01)
CPC
C07D 453/00
C07D 453/02
Applicants
  • CHIESI FARMACEUTICI S.P.A. [IT/IT]; Via Palermo, 26/A I-43100 Parma, IT
Inventors
  • AMARI, Gabriele; IT
  • ARMANI, Elisabetta; IT
  • RICCABONI, Mauro; IT
  • RIZZI, Andrea; IT
  • BAKER-GLENN, Charles; IT
  • BLACKABY, Wesley; IT
  • VAN DE POËL, Hervé; IT
  • WHITTAKER, Ben; IT
Agents
  • MINOJA, Fabrizio; BIANCHETTI BRACCO MINOJA S.r.l. Via Plinio, 63 I-20129 Milano, IT
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 3,5-DICHLORO,4-(3,4-(CYCLO-)ALKOXYPHENYL)--2-CARBONYLOXY)ETHYL)PYRIDINE DERIVATIVES AS PDE-4 INHIBITORS
(FR) DÉRIVÉS DE 3,5-DICHLORO,4-(3,4-(CYCLO-)ALCOXYPHÉNYL)--2-CARBONYLOXY)ÉTHYL)PYRIDINE UTILISÉS COMME INHIBITEURS DE PDE-4
Abstract
(EN)
The invention relates to novel 3,5-dichloro,4-(3,4-(cyclo-) alkoxyphenyl)--2-carbonyloxy)ethyl)pyridine compounds which are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.
(FR)
L'invention concerne de nouveaux composés de 3,5-dichloro,4-(3,4-(cyclo-)alcoxyphényl)--2-carbonyloxy)éthyl)pyridine qui sont à la fois des inhibiteurs de l'enzyme phosphodiestérase 4 (PDE4) et des antagonistes des récepteurs muscariniques M3, des procédés de préparation de tels composés, des compositions les contenant et leur utilisation thérapeutique.
Also published as
Latest bibliographic data on file with the International Bureau