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1. (WO2015184099) ANTI-GITR ANTIBODIES AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2015/184099 International Application No.: PCT/US2015/032895
Publication Date: 03.12.2015 International Filing Date: 28.05.2015
IPC:
A61K 39/395 (2006.01) ,C07K 16/28 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
Applicants:
AGENUS INC. [US/US]; 3 Forbes Road Lexington, MA 02421, US
MEMORIAL SLOAN-KETTERING CANCER CENTER [US/US]; 1275 York Avenue New York, New York 10065, US
LUDWIG INSTITUTE FOR CANCER RESEARCH LTD. [CH/CH]; Stadelhoferstrasse 22 CH-8001 Zurich, CH
Inventors:
LEGER, Olivier; FR
SIEBERT, Volker; DE
VAN DIJK, Marc; NL
SCHAER, David; US
TSUJI, Takemasa; US
RITTER, Gerd; US
GONZALEZ, Ana M.; US
WILSON, Nicolas S.; US
ZAPPASODI, Roberta; US
MERGHOUB, Taha; US
WOLCHOK, Jedd David; US
UNDERWOOD, Dennis J.; US
Agent:
STEFFE, Eric K.; US
Priority Data:
62/004,07128.05.2014US
62/161,25013.05.2015US
Title (EN) ANTI-GITR ANTIBODIES AND METHODS OF USE THEREOF
(FR) ANTICORPS ANTI-GITR ET LEURS PROCÉDÉS D'UTILISATION
Abstract:
(EN) The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and modulate GITR activity, e.g., enhance, activate or induce GITR activity, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as cancer and infectious diseases, by administering an antibody that specifically binds to human GITR and modulates GITR activity e.g., enhances, activates or induces GITR activity.
(FR) La présente invention concerne des anticorps qui se lient spécifiquement au récepteur lié à la famille du TNFR induit par les glucocorticoïdes (GITR), et des compositions comprenant lesdits anticorps. Dans un aspect de l'invention, les anticorps se lient spécifiquement au GITR et modulent l'activité du GITR humain, par exemple en améliorant, activant, ou induisant l'activité de GITR, au moyen de ces anticorps. La présente invention porte en outre sur des méthodes de traitement de troubles, tels que le cancer et les maladies infectieuses, par l'administration d'un anticorps qui se lie spécifiquement au GITR humain et module l'activité du GITR, par exemple en améliorant, activant ou induisant l'activité du GITR.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA2949998SG11201609721WIL249092AU2015266958EP3148579KR1020170020819
PH1/2016/502345JP2017526615EA201692458CN108064242