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1. WO2015183041 - COMPOSITION FOR PREVENTING OR TREATING STAPHYLOCOCCUS AUREUS INFECTION

Publication Number WO/2015/183041
Publication Date 03.12.2015
International Application No. PCT/KR2015/005431
International Filing Date 29.05.2015
IPC
A61K 38/14 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
14Peptides containing saccharide radicals; Derivatives thereof
A61K 38/17 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61P 31/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
A61P 31/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
10Antimycotics
CPC
A61K 38/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
14Peptides containing saccharide radicals; Derivatives thereof ; , e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
A61K 38/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
A61P 31/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
10Antimycotics
C07K 9/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
9Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
C12P 21/005
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
005Glycopeptides, glycoproteins
Applicants
  • 주식회사 녹십자 GREEN CROSS CORPORATION [KR]/[KR]
  • 부산대학교 산학협력단 PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION [KR]/[KR]
Inventors
  • 이복률 LEE, Bok Luel
  • 이민자 LEE, Min Ja
  • 이종호 LEE, Jong Ho
  • 성민영 SEONG, Min Young
  • 안동호 AHN, Dong Ho
  • 타카하시카즈에 TAKAHASHI, Kazue
  • 쿠로카와켄지 KUROKAWA, Kenji
Agents
  • 제일특허법인 FIRSTLAW P.C.
Priority Data
62/004,56429.05.2014US
62/040,45222.08.2014US
62/044,19630.08.2014US
Publication Language Korean (ko)
Filing Language Korean (KO)
Designated States
Title
(EN) COMPOSITION FOR PREVENTING OR TREATING STAPHYLOCOCCUS AUREUS INFECTION
(FR) COMPOSITION POUR LA PRÉVENTION OU LE TRAITEMENT D'UNE INFECTION PAR STAPHYLOCOCCUS AUREUS
(KO) 포도상구균 감염 질환의 예방 또는 치료용 조성물
Abstract
(EN) The present invention relates to: a composition containing, as an active ingredient, wall teichoic acid (WTA)-attached peptidoglycan (PGN); a method for preventing or treating Staphylococcus aureus infection by using the composition; and a method for preparing soluble wall teichoic acid-attached peptidoglycan (WTA-PGN), which can be used as an active ingredient in the composition. The composition of the present invention can be utilized for the prevention or treatment of Staphylococcus aureus infection by: opsonophagocytosis caused by an antigen-antibody reaction; and neutrophil-mediated phagocytosis caused by T cell activation during the early stage of infection.
(FR) La présente invention concerne : une composition contenant, comme ingrédient actif, un peptidoglycane (PGN) attaché à l'acide téichoïque de paroi (WTA) ; un procédé pour la prévention ou le traitement d'une infection par Staphylococcus aureus au moyen de la composition ; et un procédé de préparation d'un peptidoglycane attaché à l'acide téichoïque de paroi (WTA-PGN) soluble, qui peut être utilisé en tant que principe actif dans la composition. La composition selon la présente invention peut être utilisée pour la prévention ou le traitement d'une infection par Staphylococcus aureus par : une opsonophagocytose provoquée par une réaction antigène-anticorps ; et une phagocytose médiée par des neutrophiles provoquée par l'activation des lymphocytes T pendant le stade précoce d'infection.
(KO) 본 발명은 벽테이코산(WTA)-부착된 펩티도글리칸(PGN)을 유효성분으로 포함하는 조성물, 상기 조성물을 이용한 포도상구균 감염 질환의 예방 또는 치료방법 및 상기 조성물에서 유효성분으로 사용될 수 있는 가용성 벽테이코산-부착된 펩티도글리칸(WTA-PGN)을 제조하는 방법에 관한 것으로서, 본 발명의 조성물은 항원-항체 반응에 의한 옵소닌 식세포 작용(opsonophagocytosis) 및 감염 초기에 T 세포 활성화에 의한 호중구 매개의 식세포 작용 (phagocytosis)에 의해 포도상구균 감염 질환을 예방 또는 치료하는데 유용하게 사용될 수 있다.
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