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1. WO2015179691 - CELL PENETRATING PEPTIDES AND METHODS OF MAKING AND USING THEREOF

Publication Number WO/2015/179691
Publication Date 26.11.2015
International Application No. PCT/US2015/032043
International Filing Date 21.05.2015
IPC
C07K 7/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 38/05
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
05Dipeptides
A61K 38/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12Cyclic peptides ; , e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
A61K 38/465
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
465acting on ester bonds (3.1), e.g. lipases, ribonucleases
A61K 47/64
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61K 49/0039
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
0013Luminescence
0017Fluorescence in vivo
0019characterised by the fluorescent group
0021the fluorescent group being a small organic molecule
0039Coumarin dyes
Applicants
  • CYCLOPORTERS, INC. [US]/[US]
Inventors
  • PEI, Dehua
  • QIAN, Ziqing
Agents
  • COUSIN, Jonathan, M.
Priority Data
62/001,53521.05.2014US
62/158,35107.05.2015US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CELL PENETRATING PEPTIDES AND METHODS OF MAKING AND USING THEREOF
(FR) PEPTIDES PÉNÉTRANT DANS LES CELLULES ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
Abstract
(EN)
Disclosed herein are compounds having activity as cell penetrating peptides. In some examples, the compounds can comprise a cell penetrating peptide moiety and a cargo moiety. The cargo moiety can comprise one or more detectable moieties, one or more therapeutic moieties, one or more targeting moieties, or any combination thereof. In some examples, the cell penetrating peptide moiety is cyclic. In some examples, the cell penetrating peptide moiety and cargo moiety together are cyclic. In some examples, the cell penetrating peptide moiety is cyclic and the cargo moiety is appended to the cyclic cell penetrating peptide moiety structure. In some examples, the cargo moiety is cyclic and the cell penetrating peptide moiety is cyclic, and together they form a fused bicyclic system.
(FR)
L'invention concerne des composés présentant une activité en tant que peptides pénétrant dans les cellules. Dans certains exemples, les composés peuvent comprendre un fragment de peptide pénétrant dans une cellule et un fragment cargo. Le fragment cargo peut comprendre un ou plusieurs fragments détectables, un ou plusieurs fragments thérapeutiques, un ou plusieurs fragments de ciblage, ou n'importe quelle combinaison de ceux-ci. Dans certains exemples, le fragment de peptide pénétrant dans les cellules est cyclique. Dans certains exemples, le fragment de peptide pénétrant dans les cellules et le fragment cargo sont conjointement cycliques. Dans certains exemples, le fragment de peptide pénétrant dans les cellules est cyclique et le fragment cargo est ajouté à la structure de fragment de peptide pénétrant dans les cellules. Dans certains exemples, le fragment cargo est cyclique et le fragment de peptide pénétrant dans les cellules est cyclique, et ensemble ils forment un système bicyclique condensé.
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