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1. WO2015168157 - DEVICES, METHODS, AND SYSTEMS OF FUNCTIONAL OPTICAL COHERENCE TOMOGRAPHY

Publication Number WO/2015/168157
Publication Date 05.11.2015
International Application No. PCT/US2015/028053
International Filing Date 28.04.2015
IPC
A61B 5/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
A61B 3/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
3Apparatus for testing the eyes; Instruments for examining the eyes
10Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
CPC
A61B 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
1Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes
04combined with photographic or television appliances
A61B 3/102
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
3Apparatus for testing the eyes; Instruments for examining the eyes
10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
102for optical coherence tomography [OCT]
A61B 3/1233
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
3Apparatus for testing the eyes; Instruments for examining the eyes
10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
12for looking at the eye fundus, e.g. ophthalmoscopes
1225using coherent radiation
1233for measuring blood flow, e.g. at the retina
A61B 5/0066
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
0059using light, e.g. diagnosis by transillumination, diascopy, fluorescence
0062Arrangements for scanning
0066Optical coherence imaging
A61B 5/0073
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
0059using light, e.g. diagnosis by transillumination, diascopy, fluorescence
0073by tomography, i.e. reconstruction of 3D images from 2D projections
A61B 5/0205
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
0205Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
Applicants
  • NORTHWESTERN UNIVERSITY [US]/[US]
Inventors
  • YI, Ji
  • LIU, Wenzhong
  • BACKMAN, Vadim
  • ZHANG, Hao, F.
Agents
  • GEORGE, Christopher, N.
Priority Data
61/985,27828.04.2014US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DEVICES, METHODS, AND SYSTEMS OF FUNCTIONAL OPTICAL COHERENCE TOMOGRAPHY
(FR) DISPOSITIFS, PROCÉDÉS ET SYSTÈMES DE TOMOGRAPHIE PAR COHÉRENCE OPTIQUE FONCTIONNELLE
Abstract
(EN)
The present disclosure provides systems and methods for the determining a rate of change of one or more analyte concentrations in a target using non invasive non contact imaging techniques such as OCT. Generally, OCT data is acquired and optical information is extracted from OCT scans to quantitatively determine both a flow rate of fluid in the target and a concentration of one or more analytes. Both calculations can provide a means to determine a change in rate of an analyte over time. Example methods and systems of the disclosure may be used in assessing metabolism of a tissue, where oxygen is the analyte detected, or other functional states, and be generally used for the diagnosis, monitoring and treatment of disease.
(FR)
La présente invention concerne des systèmes et des procédés pour la détermination d'un taux de changement d'une ou de plusieurs concentrations d'analytes dans une cible à l'aide de techniques d'imagerie sans contact non invasives comme l'OCT. D'une manière générale, des données d'OCT sont acquises et l'information optique est extraite à partir de balayages d'OCT pour déterminer de manière quantitative à la fois un débit de fluide dans la cible et une concentration d'un ou de plusieurs analytes. Les deux calculs peuvent fournir un moyen pour déterminer un changement de taux d'un analyte au cours du temps. Des procédés et des systèmes exemplaires de l'invention peuvent être utilisés dans l'évaluation du métabolisme d'un tissu, dans lequel l'oxygène est l'analyte détecté, ou d'autres états fonctionnels, et être généralement utilisés pour le diagnostic, la surveillance et le traitement d'une maladie.
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