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1. WO2015165931 - IMIDAZO[1,2-A]PYRIDINES AS STIMULATORS OF SOLUBLE GUANYLATE CYCLASE FOR TREATING CARDIOVASCULAR DISEASES

Publication Number WO/2015/165931
Publication Date 05.11.2015
International Application No. PCT/EP2015/059275
International Filing Date 29.04.2015
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
02
Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
04
Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
12
Antihypertensives
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7
Drugs for disorders of the blood or the extracellular fluid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7
Drugs for disorders of the blood or the extracellular fluid
02
Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
C07D 471/04 (2006.01)
A61K 31/437 (2006.01)
A61P 9/00 (2006.01)
A61P 9/02 (2006.01)
A61P 9/04 (2006.01)
A61P 9/10 (2006.01)
CPC
A61K 31/437
A61K 31/444
A61K 45/06
C07D 471/04
Applicants
  • BAYER PHARMA AKTIENGESELLSCHAFT [DE/DE]; Müllerstr. 178 13353 Berlin, DE
Inventors
  • VAKALOPOULOS, Alexandros; DE
  • FOLLMANN, Markus; DE
  • WUNDER, Frank; DE
  • STASCH, Johannes-Peter; IT
  • MARQUARDT, Tobias; DE
  • DIETZ, Lisa; DE
  • LI, Volkhart Min-Jian; DE
  • RAY, Nicholas, Charles; GB
  • VUJASINOVIC, Ines; HR
Agents
  • BIP PATENTS; c/o Bayer Intellectual Property GmbH Alfred-Nobel-Str. 10 40789 Monheim am Rhein, DE
Priority Data
14166910.102.05.2014EP
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) IMIDAZO[1,2-A]PYRIDINE ALS STIMULATOREN DER LÖSLICHEN GUANYLATCYCLASE ZUR BEHANDLUNG VON KARDIOVASKULÄREN ERKRANKUNGEN
(EN) IMIDAZO[1,2-A]PYRIDINES AS STIMULATORS OF SOLUBLE GUANYLATE CYCLASE FOR TREATING CARDIOVASCULAR DISEASES
(FR) IMIDAZO[1,2-A]PYRIDINES UTILISÉES EN TANT QUE STIMULATEURS DE LA GUANYLATE CYCLASE POUR TRAITER DES MALADIES CARDIOVASCULAIRES
Abstract
(DE)
Die vorliegende Anmeldung betrifft neue Heterocyclyl- und Heteroaryl-Substituierte Imidazo[1,2- a]pyridine, Verfahren zu ihrer Herstellung, ihre Verwendung allein oder in Kombinationen zur Behandlung und/oder Prophylaxe von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prophylaxe von Krankheiten, insbesondere zur Behandlung und/oder Prophylaxe von kardiovaskulären Erkrankungen.
(EN)
The application relates to novel heterocyclyl- and hetaryl-substituted imidazo[1,2-a]pyridines, methods for producing same, the use thereof alone or in combinations for treating and/or preventing diseases, and the use thereof for producing medicaments for treating and/or preventing diseases, in particular for treating and/or preventing cardiovascular diseases.
(FR)
L'invention concerne de nouvelles imidazo[1,2-a]pyridines substituées par hétérocyclyle et par hétéroaryle, des procédés pour les produire, leur utilisation individuellement ou en combinaisons pour assurer le traitement et/ou la prophylaxie de maladies, ainsi que leur utilisation pour la production de médicaments en vue du traitement et/ou de la prophylaxie de maladies, notamment du traitement et/ou de la prophylaxie de maladies cardiovasculaires.
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