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1. WO2015158575 - SYNTHESIS OF AMPHIPHILIC CALIXARENE GLYCOSIDE DETERGENTS AND USE OF SAME FOR EXTRACTING AND STABILIZING NATIVE FUNCTIONAL MEMBRANE PROTEINS

Publication Number WO/2015/158575
Publication Date 22.10.2015
International Application No. PCT/EP2015/057544
International Filing Date 08.04.2015
IPC
C07H 13/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
13Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
02by carboxylic acids
04having the esterifying carboxyl radicals attached to acyclic carbon atoms
C07H 13/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
13Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
12by acids having the group -X-C (=X)-X-, or halides thereof, in which X means nitrogen, oxygen, sulfur, selenium, or tellurium, e.g. carbonic acid, carbamic acid
C07H 15/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
02Acyclic radicals, not substituted by cyclic structures
04attached to an oxygen atom of a saccharide radical
B01D 11/04 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
11Solvent extraction
04of solutions which are liquid
CPC
B01D 11/0288
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
11Solvent extraction
02of solids
0288Applications, solvents
C07H 13/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
13Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
C07H 13/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
13Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
02by carboxylic acids
04having the esterifying carboxyl radicals attached to acyclic carbon atoms
C07H 13/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
13Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
12by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
C07H 15/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
02Acyclic radicals, not substituted by cyclic structures
04attached to an oxygen atom of the saccharide radical
C07H 15/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
20Carbocyclic rings
24Condensed ring systems having three or more rings
Applicants
  • CALIXAR [FR]/[FR]
Inventors
  • DAUVERGNE, Julien
Agents
  • SCHMIDT, Martin
Priority Data
1406643.514.04.2014GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SYNTHESIS OF AMPHIPHILIC CALIXARENE GLYCOSIDE DETERGENTS AND USE OF SAME FOR EXTRACTING AND STABILIZING NATIVE FUNCTIONAL MEMBRANE PROTEINS
(FR) SYNTHÈSE DE DÉTERGENTS AMPHIPHILES DE GLYCOSIDE DE CALIXARÈNE ET LEUR UTILISATION POUR L'EXTRACTION ET LA STABILISATION DE PROTÉINES MEMBRANAIRES FONCTIONNELLES NATURELLES
Abstract
(EN) Calixarene compound according to formula (I) wherein: R1 represents a linear or branched C(1-16) alkyl group; R2 represents an hydrogen atom or a methyl group; R3 is identical to R1 or R2 group; R4 represents a saccharide residue, in which hydroxyl groups are not protected; R5 is identical to R4, or is absent; L is a linker, which is selected from the group consisting of 1,2,3-triazole function, amide function, thiourea function, or is absent; Z is identical to L or absent; 0 ≤ x1 ≤ 3, wherein x1 is an integer; 0 ≤ y1 ≤ 3, wherein y1 is an integer; - x2 is identical to x1 or equal to 0; - y2 is identical to y1 or equal to 0; - X = O, S or is absent; Y is identical to X or is absent.
(FR) L'invention concerne un composé de type calixarène selon la formule (I) dans laquelle : R1 représente un groupe alkyle linéaire ou ramifié en C(1-16) ; R2 représente un atome d'hydrogène ou un groupe méthyle ; R3 est identique au groupe R1 ou R2 ; R4 représente un résidu saccharide, dans lequel des groupes hydroxyle ne sont pas protégés ; R5 est identique à R4 ou est absent ; L est un lieur, qui est choisi dans le groupe constitué par une fonction 1,2,3-triazole, une fonction amide, une fonction thio-urée ou est absent ; Z est identique à L ou absent ; 0 ≤ x1 ≤ 3, x1 étant un nombre entier ; 0 ≤ y1 ≤ 3, y1 étant un nombre entier ; -x2 est identique à x1 ou égal à 0 ; - y2 est identique à y1 ou égal à 0 ; - X = O, S ou est absent ; Y est identique à X ou est absent.
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