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1. (WO2015157704) METHODS AND COMPOSITIONS FOR DETECTING MISFOLDED PROTEINS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2015/157704 International Application No.: PCT/US2015/025432
Publication Date: 15.10.2015 International Filing Date: 10.04.2015
IPC:
G01N 33/52 (2006.01) ,G01N 33/68 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
52
Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
YALE UNIVERSITY [US/US]; Two Whitney Avenue New Haven, CT 06511, US
Inventors:
BUHIMSCHI, Irina; US
BUHIMSCHI, Catalin, S.; US
CHOMA, Michael; US
TAGARE, Hemant; US
JONAS, Stephan, Michael; DE
Agent:
DIPIETRANTONIO, Heather, J.; US
Priority Data:
61/978,15810.04.2014US
Title (EN) METHODS AND COMPOSITIONS FOR DETECTING MISFOLDED PROTEINS
(FR) PROCÉDÉS ET COMPOSITIONS DE DÉTECTION DE PROTÉINES MAL REPLIÉES
Abstract:
(EN) Various aspects and embodiments of the present disclosure are directed to methods and compositions (e.g., kits) for the identification of subjects with misfolded proteins in their urine. For example, methods and compositions for determining that a urine sample from a pregnant woman contains or does not contain misfolded are provided. In some embodiments, the presence of misfolded proteins in a urine sample from a pregnant woman is an indication of preeclampsia.
(FR) Divers aspects et modes de réalisation de la présente invention concernent des procédés et des compositions (par exemple, des kits) pour l'identification de sujets ayant des protéines mal repliées dans leur urine. L'invention concerne, par exemple, des procédés et compositions permettant de déterminer qu'un échantillon d'urine d'une femme enceinte contient ou ne contient pas de protéines mal repliées. Dans certains modes de réalisation, la présence de protéines mal repliées dans un échantillon d'urine d'une femme enceinte est une indication de pré-éclampsie.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)