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1. WO2015155704 - AN IMPROVED PROCESS FOR THE PREPARATION OF PRAMIPEXOLE DIHYDROCHLORIDE MONOHYDRATE

Publication Number WO/2015/155704
Publication Date 15.10.2015
International Application No. PCT/IB2015/052542
International Filing Date 08.04.2015
IPC
C07D 277/82 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
277Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
60condensed with carbocyclic rings or ring systems
62Benzothiazoles
68with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
82Nitrogen atoms
C07B 31/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
31Reduction in general
CPC
C07D 277/60
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
277Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
60condensed with carbocyclic rings or ring-systems
C07D 277/82
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
277Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
60condensed with carbocyclic rings or ring-systems
62Benzothiazoles
68with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
82Nitrogen atoms
Applicants
  • PIRAMAL ENTERPRISES LIMITED [IN]/[IN]
Inventors
  • PATIL, Pravin
  • PANSARE, Prakash
  • JAGTAP, Ashutosh
  • KRISHNAMURTHY, Dhileepkumar
Priority Data
1307/MUM/201409.04.2014IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) AN IMPROVED PROCESS FOR THE PREPARATION OF PRAMIPEXOLE DIHYDROCHLORIDE MONOHYDRATE
(FR) PROCÉDÉ AMÉLIORÉ DE PRÉPARATION DU MONOHYDRATE DU DICHLORHYDRATE DE PRAMIPEXOLE
Abstract
(EN)
The present invention relates to an improved process for the preparation of the dihydrochloride monohydrate salt of (S)-2-amino-4,5,6,7-tetrahydro-6- (propylamino)benzothiazole (the compound of formula I) comprising reacting the compound of formula II with n-propanal and sodium borohydride using a mixture of methanol and dichloromethane (DCM) as the solvent to obtain the compound of formula I; followed by converting the compound of formula I into its monohydrochloride salt; purifying the monohydrochloride salt of the compound of formula I; and finally converting the pure monohydrochloride salt of the compound of formula I into the dihydrochloride monohydrate salt.
(FR)
La présente invention concerne un procédé amélioré de préparation du sel monohydrate du dichlorhydrate de (S)-2-amino-4,5,6,7-tétrahydro-6-(propylamino)benzothiazole (le composé de formule I) consistant à faire réagir le composé de formule II avec du n-propanal et du borohydrure de sodium en faisant appel à un mélange de méthanol et de dichlorométhane (DCM) en tant que solvant afin d'obtenir le composé de formule I ; puis à convertir le composé de formule I en son sel monochlorhydrate ; à purifier ledit sel monochlorhydrate du composé de formule I ; et enfin à convertir ledit sel monochlorhydrate pur du composé de formule I en sel monohydrate de dichlorhydrate.
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