WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
maximize
Machine translation
1. (WO2015155704) AN IMPROVED PROCESS FOR THE PREPARATION OF PRAMIPEXOLE DIHYDROCHLORIDE MONOHYDRATE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2015/155704    International Application No.:    PCT/IB2015/052542
Publication Date: 15.10.2015 International Filing Date: 08.04.2015
IPC:
C07D 277/82 (2006.01), C07B 31/00 (2006.01)
Applicants: PIRAMAL ENTERPRISES LIMITED [IN/IN]; Piramal Tower Ganpatrao Kadam Marg Lower Parel Mumbai 400013 (IN)
Inventors: PATIL, Pravin; (IN).
PANSARE, Prakash; (IN).
JAGTAP, Ashutosh; (IN).
KRISHNAMURTHY, Dhileepkumar; (IN)
Priority Data:
1307/MUM/2014 09.04.2014 IN
Title (EN) AN IMPROVED PROCESS FOR THE PREPARATION OF PRAMIPEXOLE DIHYDROCHLORIDE MONOHYDRATE
(FR) PROCÉDÉ AMÉLIORÉ DE PRÉPARATION DU MONOHYDRATE DU DICHLORHYDRATE DE PRAMIPEXOLE
Abstract: front page image
(EN)The present invention relates to an improved process for the preparation of the dihydrochloride monohydrate salt of (S)-2-amino-4,5,6,7-tetrahydro-6- (propylamino)benzothiazole (the compound of formula I) comprising reacting the compound of formula II with n-propanal and sodium borohydride using a mixture of methanol and dichloromethane (DCM) as the solvent to obtain the compound of formula I; followed by converting the compound of formula I into its monohydrochloride salt; purifying the monohydrochloride salt of the compound of formula I; and finally converting the pure monohydrochloride salt of the compound of formula I into the dihydrochloride monohydrate salt.
(FR)La présente invention concerne un procédé amélioré de préparation du sel monohydrate du dichlorhydrate de (S)-2-amino-4,5,6,7-tétrahydro-6-(propylamino)benzothiazole (le composé de formule I) consistant à faire réagir le composé de formule II avec du n-propanal et du borohydrure de sodium en faisant appel à un mélange de méthanol et de dichlorométhane (DCM) en tant que solvant afin d'obtenir le composé de formule I ; puis à convertir le composé de formule I en son sel monochlorhydrate ; à purifier ledit sel monochlorhydrate du composé de formule I ; et enfin à convertir ledit sel monochlorhydrate pur du composé de formule I en sel monohydrate de dichlorhydrate.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)