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1. WO2015155231 - NOVEL CELL-PERMEABLE SUCCINATE COMPOUNDS

Publication Number WO/2015/155231
Publication Date 15.10.2015
International Application No. PCT/EP2015/057606
International Filing Date 08.04.2015
IPC
A61K 31/225 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
225Polycarboxylic acids
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07C 323/25 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
323Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
23containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
24having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
25the carbon skeleton being acyclic and saturated
C07D 281/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
281Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
18Eight-membered rings
C07D 417/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
CPC
A61K 2800/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2800Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
10General cosmetic use
A61K 31/155
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines
155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
A61K 31/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
A61K 31/185
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
A61K 31/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
A61K 31/265
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
265of carbonic, thiocarbonic, or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
Applicants
  • NEUROVIVE PHARMACEUTICAL AB [SE]/[SE]
Inventors
  • ELMÉR, Eskil
  • HANSSON, Magnus Joakim
  • EHINGER, Karl Henrik Johannes
  • MOSS, Steven
Agents
  • CHAS. HUDE A/S
Priority Data
PA 2014 7019008.04.2014DK
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL CELL-PERMEABLE SUCCINATE COMPOUNDS
(FR) NOUVEAUX COMPOSÉS DE SUCCINATE PERMÉABLES À TRAVERS LES CELLULES
Abstract
(EN)
The present invention provides novel cell-permeable succinates and cell permeable precursors of succinate aimed at increasing ATP-production in mitochondria. The main part of ATP produced and utilized in the eukaryotic cell originates from mitochondrial oxidative phosphorylation, a process to which high-energy electrons are provided by the Kreb's cycle. Not all Kreb's cycle intermediates are readily permeable to the cellular membrane, one of them being succinate. The provision of the novel cell permeable succinates is envisaged to allow passage over the cellular membrane and thus the cell permeable succinates can be used to enhance mitochondrial ATP-output.
(FR)
La présente invention concerne de nouveaux succinates perméables à travers les cellules et des précurseurs perméables aux cellules de succinate visant à augmenter la production d'ATP dans les mitochondries. La majeure partie de l'ATP produit et utilisé dans la cellule eucaryote provident de la phosphorylation oxydative mitochondriale, un processus auquel des électrons à haute énergie sont fournis par le cycle de Krebs. Les intermédiaires du cycle de Krebs ne sont pas facilement perméables à la membrane cellulaire, l'un d'eux étant le succinate. La fourniture des nouveaux succinates perméables aux cellules devrait permettre le passage à travers la membrane cellulaire et, par conséquent, les succinates perméables aux cellules peuvent être utilisés pour augmenter le débit d'ATP mitochondrial.
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