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1. WO2015155230 - PRODRUGS OF SUCCINIC ACID FOR INCREASING ATP PRODUCTION

Publication Number WO/2015/155230
Publication Date 15.10.2015
International Application No. PCT/EP2015/057605
International Filing Date 08.04.2015
IPC
C07D 319/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
319Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
041,3-Dioxanes; Hydrogenated 1,3-dioxanes
06not condensed with other rings
C07C 69/40 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
34Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
40Succinic acid esters
C07C 69/708 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
66Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, -CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
67of saturated acids
708Ethers
C07D 321/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
321Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/-C07D319/174
02Seven-membered rings
04not condensed with other rings
061, 3-Dioxepines; Hydrogenated 1,3-dioxepines
C07D 323/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
323Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
C07D 273/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
273Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/-C07D271/183
02having two nitrogen atoms and only one oxygen atom
CPC
A61K 31/155
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines
155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
A61K 31/225
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
225Polycarboxylic acids
A61K 31/4035
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403condensed with carbocyclic rings, e.g. carbazole
4035Isoindoles, e.g. phthalimide
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K 8/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
33containing oxygen
36Carboxylic acids; Salts or anhydrides thereof
A61P 21/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
Applicants
  • NEUROVIVE PHARMACEUTICAL AB [SE]/[SE]
Inventors
  • ELMÉR, Eskil
  • HANSSON, Magnus Joakim
  • EHINGER, Karl Henrik Johannes
  • MOSS, Steven
Agents
  • CHAS. HUDE A/S
Priority Data
PA 2014 7018708.04.2014DK
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PRODRUGS OF SUCCINIC ACID FOR INCREASING ATP PRODUCTION
(FR) PROMÉDICAMENTS D'ACIDE SUCCINIQUE POUR AUGMENTER LA PRODUCTION D'ATP
Abstract
(EN)
The present invention provides novel cell-permeable succinates and cell permeable precursors of succinate aimed at increasing ATP-production in mitochondria. The main part of ATP produced and utilized in the eukaryotic cell originates from mitochondrial oxidative phosphorylation, a process to which high-energy electrons are provided by the Kreb's cycle. Not all Kreb's cycle intermediates are readily permeable to the cellular membrane, one of them being succinate. The provision of the novel cell permeable succinates is envisaged to allow passage over the cellular membrane and thus the cell permeable succinates can be used to enhance mitochondrial ATP-output.
(FR)
La présente invention concerne de nouveaux succinates pénétrant dans les cellules et de nouveaux précurseurs de succinate pénétrant dans les cellules visant à augmenter la production d'ATP dans les mitochondries. La majeure partie de l'ATP produit et utilisé dans la cellule eucaryote est issue de la phosphorylation oxydative mitochondriale, un procédé dans lequel des électrons à haute énergie sont fournis par le cycle de Krebs. Les intermédiaires du cycle de Krebs ne pénètrent pas tous facilement dans la membrane cellulaire, l'un d'eux étant du succinate. L'utilisation des nouveaux succinates pénétrant dans les cellules est envisagée pour permettre le passage à travers la membrane cellulaire et, par conséquent, les succinates pénétrant dans les cellules peuvent être utilisés pour améliorer la production d'ATP mitochondriale.
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