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1. WO2015154031 - METHOD FOR PREPARING AMG 416

Publication Number WO/2015/154031
Publication Date 08.10.2015
International Application No. PCT/US2015/024347
International Filing Date 03.04.2015
IPC
C07K 1/02 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
02in solution
C07K 7/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
A61K 38/08 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08Peptides having 5 to 11 amino acids
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 5/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
5Drugs for disorders of the endocrine system
18of the parathyroid hormones
20for decreasing, blocking or antagonising the activity of PTH
C07K 1/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General methods for the preparation of peptides ; , i.e. processes for the organic chemical preparation of peptides or proteins of any length
02in solution
C07K 1/1075
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General methods for the preparation of peptides ; , i.e. processes for the organic chemical preparation of peptides or proteins of any length
107by chemical modification of precursor peptides
1072by covalent attachment of residues or functional groups
1075by covalent attachment of amino acids or peptide residues
C07K 7/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
Applicants
  • AMGEN INC. [US]/[US]
Inventors
  • BEZEMER, Jeroen
  • CHEN, Ying
  • CROCKETT, Richard
  • CROSSLEY, Kevin
  • CUI, Sheng
  • HUANG, Liang
  • JONES, Sian
  • LOWER, Asher
  • RANGANATHAN, Krishnakumar
Agents
  • HARLOCKER, Susan L.
Priority Data
61/974,89903.04.2014US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR PREPARING AMG 416
(FR) PROCÉDÉ DE PRÉPARATION D'AMG 416
Abstract
(EN) A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided. AMG 416 is a synthetic, eight amino-acid selective peptide agonist of the calcium sensing receptor. It is being developed as an intravenous treatment of secondary hyperparathyroidism (SHPT) in hemodialysis patients with chronic kidney disease - mineral and bone disorder (CKD-MBD).
(FR) L'invention concerne un procédé de préparation d'AMG 416, ou d'un sel pharmaceutiquement acceptable de celui-ci. AMG 416 est un peptide agoniste sélectif de synthèse à 8 acides aminés du récepteur sensible au calcium. Il a été développé pour servir de traitement intraveineux de l'hyperparathyroïdisme secondaire (SHPT) chez les patients d'hémodialyse présentant des troubles minéraux et osseux de la maladie rénale chronique (CKD-MBD).
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CL2016-2513This application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
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