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1. WO2015140748 - SILDENAFIL SOLUTIONS AND METHODS OF MAKING AND USING SAME

Publication Number WO/2015/140748
Publication Date 24.09.2015
International Application No. PCT/IB2015/052014
International Filing Date 19.03.2015
IPC
A01N 43/90 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
90having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
CPC
A61K 31/519
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61K 47/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen, ; e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
A61K 47/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen, ; e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
A61K 9/0056
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0053Mouth and digestive tract, i.e. intraoral and peroral administration
0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
A61K 9/0058
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0053Mouth and digestive tract, i.e. intraoral and peroral administration
0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
0058Chewing gums
A61K 9/006
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0053Mouth and digestive tract, i.e. intraoral and peroral administration
006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
Applicants
  • VIGOROUS SOLUTIONS LTD.
Inventors
  • ROGOSNITZKY, Moshe
  • ABOOHI, Morris
Priority Data
61/955,29919.03.2014US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SILDENAFIL SOLUTIONS AND METHODS OF MAKING AND USING SAME
(FR) SOLUTIONS À BASE DE SILDÉNAFIL ET PROCÉDÉS DE PRÉPARATION ET D'UTILISATION DE CES SOLUTIONS
Abstract
(EN)
The invention relates to compositions containing dissolved sildenafil citrate and methods of producing such compositions, wherein sildenafil citrate is dissolved in water mixed with one or more alcohols, and optionally a ketone may be used to enhance solubility. It also relates to methods of using such compositions containing dissolved sildenafil citrate utilizing dosages significantly below existing therapeutic dosages of sildenafil citrate.
(FR)
L'invention concerne des compositions contenant du citrate de sildénafil dissous et des procédés de production de telles compositions, le citrate de sildénafil étant dissous dans de l'eau mélangée avec un ou plusieurs alcools, et éventuellement une cétone pouvant être utilisée pour améliorer la solubilité. L'invention concerne également des procédés d'utilisation de telles compositions contenant du citrate de sildénafil dissous, utilisant des dosages considérablement au-dessous des dosages thérapeutiques existants de citrate de sildénafil.
Latest bibliographic data on file with the International Bureau