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1. WO2015138803 - METHOD FOR IDENTIFYING KIDNEY ALLOGRAFT RECIPIENTS AT RISK FOR CHRONIC INJURY

Publication Number WO/2015/138803
Publication Date 17.09.2015
International Application No. PCT/US2015/020291
International Filing Date 12.03.2015
IPC
G01N 33/68 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
C12Q 2600/118
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
118Prognosis of disease development
C12Q 2600/158
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
158Expression markers
Applicants
  • ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI [US]/[US]
  • WESTERN SYDNEY LOCAL HEALTH DISTRICT [AU]/[AU]
Inventors
  • MURPHY, Barbara
  • ZHANG, Weijia
  • O'CONNELL, Philip J.
Agents
  • LUDWIG, S. Peter
Priority Data
61/951,65112.03.2014US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR IDENTIFYING KIDNEY ALLOGRAFT RECIPIENTS AT RISK FOR CHRONIC INJURY
(FR) PROCÉDÉ D’IDENTIFICATION DE RECEVEURS D’ALLOGREFFE DE REIN À RISQUE DE LÉSION CHRONIQUE
Abstract
(EN) A method for identifying a renal allograft recipient at risk for chronic allograft damage or interstutial fibrosis and tubular atrophy (IF/TA) by comparing the transcription level of a preselected gene signature set with the transcription level of a comparison standard, and diagnosing the recipient as being at risk for chronic allograft damage if the transcription level of the preselected gene signature set is significantly higher than the transcription level of the comparison standard.
(FR) La présente invention concerne un procédé d’identification d’un receveur d’allogreffe rénale à risque de lésion d’allogreffe chronique ou de fibrose interstitielle et d’atrophie tubulaire (IF/TA) par comparaison du taux de transcription d’un ensemble de signature génique présélectionné au taux de transcription d’un standard de comparaison, et de diagnostic du receveur comme étant à risque de lésion d’allogreffe chronique si le taux de transcription de l’ensemble de signature génique présélectionné est significativement supérieur au taux de transcription du standard de comparaison.
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